调节性T细胞在人类免疫缺陷病毒感染过程中机制的研究进展

Advances in the mechanism of regulatory T cells in human immunodeficiency virus infection

调节性T细胞(Tregs)是人类免疫缺陷病毒(HIV)感染的靶细胞,其发挥免疫抑制和免疫调节作用。为深入理解Tregs在HIV感染和治疗中的作用机制,本文总结了Tregs的功能特点和分型,探讨了Tregs在HIV感染不同阶段的动态变化,并关注其在外周血和组织中的改变。此外,本文还探讨了Tregs作为HIV病毒库的机制,以及Tregs作为HIV治疗靶点的机遇与挑战,提出了未来研究的方向和临床应用的可能性。

Regulatory T cells(Tregs)are not only the target cells of human immunodeficiency virus(HIV)infection,but also critical mediators of immunosuppression and immune regulation.To deepen the understanding of the complex mechanisms of Tregs in HIV infection and treatment,this paper summarizes the functions,characteristics,and classifications of Tregs.It discusses the dynamic changes of Tregs at different stages of HIV infection,with a focus on their changes in peripheral blood and tissues.Additionally,the paper explores the mechanisms of Tregs as a reservoir of HIV,the opportunities and challenges of Tregs as a therapeutic target for HIV,and proposes future research directions and the possibility of clinical application.