生命全程路径与慢性非传染性疾病防治

Life course approach and preventive strategies for non-communicable diseases

本文通过从慢性非传染性疾病(NCDs)胎源学说和现有探讨生命全程对慢性病影响的因果机制模型,展开对生命全程理论在NCDs防治策略中的作用进行综述。从生命全程的角度总结了慢性病发生和发展过程,强调能够通过早期识别高风险表型和风险标记,在生命早期提供及时的干预措施,支持当前NCDs第一级预防的努力。最后提出WHO倡导的生命全程路径与可持续发展目标协同作用的政策建议。

This article reviews the role of the life course concept in the prevention and treatment strategies of non-communicable diseases(NCDs)from the fetal origins of NCDs and the existing causal mechanism models to explore the influences of the life course on NCDs.This article summarizes the occurrence and development of NCDs from a life course perspective,emphasizing that it can provide timely interventions in early life through early identification of high-risk phenotypes and risk markers,and support current efforts for primary prevention of NCDs.At the end,the policy recommendations on synergies between a life course approach to health with sustainable development goals advocated by WHO are addressed.