细胞周期蛋白依赖性激酶4及乳腺癌耐药蛋白表达与乳腺癌病理特征及预后的相关性研究

Correlation among CDK4, BCRP expression and pathological features, prognosis of breast cancer

目的分析细胞周期蛋白依赖性激酶4(cyclin-dependent kinase 4,CDK4)及乳腺癌耐药蛋白(breast cancer resistant protein,BCRP)表达与乳腺癌病理特征及预后的相关性。方法选取2020年1月至2021年6月商丘市第一人民医院收治的132例乳腺癌患者,采集所有患者手术切除的乳腺癌组织和癌旁组织,采用免疫组织化学染色法检测CDK4和BCRP表达情况,收集患者临床资料,分析CDK4和BCRP表达与病理特征及预后的关系。结果相较于癌旁组织,乳腺癌组织中CDK4、BCRP阳性表达率高(χ^(2)=71.17,P<0.001;χ^(2)=86.34,P<0.001);CDK4、BCRP阳性表达与分化程度、TNM分期、淋巴结转移有关(χ^(2)=8.71,P=0.003;χ^(2)=6.07,P=0.014;χ^(2)=5.70,P=0.017;χ^(2)=9.59,P=0.002;χ^(2)=5.64,P=0.018;χ^(2)=4.79,P=0.029)。Kaplan-Meier分析显示,CDK4、BCRP阴性表达组的累积生存率高于阳性表达组(Log-Rankχ^(2)=4.138,P=0.042;Log-Rankχ^(2)=3.882,P=0.049);分化程度、TNM分期、淋巴结转移、CDK4表达、BCRP表达是乳腺癌患者预后的独立影响因素(HR=1.910,P=0.034;HR=1.483,P=0.026;HR=1.912,P=0.029;HR=1.582,P=0.014;HR=1.972,P=0.002)。结论CDK4和BCRP在乳腺癌组织中阳性表达,其表达与病理特征有关,且对乳腺癌患者预后有一定的评估价值。

ObjectiveTo analyze the correlation of cyclin-dependent kinase 4(CDK4)and breast cancer resistance protein(BCRP)expression with pathological features and prognosis of breast cancer.MethodsFrom Jan.2020 to Jun.2021,132 breast cancer patients admitted to our hospital were chosen.The surgically removed breast cancer tissues and adjacent tissues of all patients were collected,and the expressions of CDK4 and BCRP were detected by immunohistochemical staining.Clinical data of all patients were collected,and the correlation among CDK4,BCRP expression and pathological features,prognosis was analyzed.ResultsThe positive expression rates of CDK4 and BCRP in breast cancer tissues were higher than those in adjacent tissues(P<0.05);The positive expression rate of CDK4 and BCRP was associated with differentiation degree,TNM stage and lymph node metastasis(all P<0.05);Kaplan-Meier analysis showed that the cumulative survival rate of CDK4 and BCRP negative expression group was higher than that of positive expression group(P<0.05);Differentiation degree,TNM stage,lymph node metastasis,CDK4 expression and BCRP expression were independent prognostic factors for overall survival of breast cancer patients(all P<0.05).ConclusionsCDK4 and BCRP have high positive expression rates in breast cancer tissues,and their expression is related to pathological features,with certain value in evaluating the prognosis of breast cancer patients.