褪黑素对成骨细胞作用机制的研究进展

Research progress on mechanism of action of melatonin on osteoblast

成骨细胞对于骨质疏松等骨代谢疾病的发生具有重要作用。褪黑素作为天然的抗衰老激素,对成骨细胞氧化应激、细胞分化、细胞自噬、细胞凋亡、铁死亡具有改善作用。笔者就以上作用机制进行详细阐述,为进一步探索褪黑素影响成骨细胞的作用机制以及骨质疏松的防治提供研究思路和依据。

Osteoblasts play an important role in the occurrence of bone metabolic diseases such as osteoporosis.As a natural anti-aging hormone,melatonin can improve oxidative stress,cell differentiation,apoptosis,autophagy and ferroptosisof osteoblasts.The above mechanisms of action are described in detail in this paper,which provides research ideas and basis for further exploring the mechanism of melatonin affecting osteoblasts and the prevention and treatment of osteoporosis.