STING信号通路在骨质疏松中作用的研究进展

Research progress of STING pathway in osteoporosis

目的概述STING信号通路在骨质疏松中的作用机制与研究成果,从而为骨质疏松的治疗提供新的思路。方法于2023年11月在PubMed和中国知网数据库中以“STING、osteoporosis、osteoblast、osteoclast、IFN-β、NF-κB、type H vessels”为英文检索词进行检索,以“STING信号通路、成骨细胞、破骨细胞、IFN-β、NF-κB、H型血管”为中文检索词进行检索。结果通过阅读标题及摘要进行文献筛选,最终引用论文数41篇。结论STING通路为骨质疏松症中的治疗提供了新的方向。激活STING/IFN-β信号通路可抑制破骨细胞分化,抑制骨吸收。而STING/NF-κB信号可导致骨吸收增加、骨形成减少。此外,STING信号通路的激活可抑制具有成骨能力的H型血管的产生,从而抑制骨形成。因此,STING通路在骨质疏松疾病进展中具有双重调控作用,调控STING通路的不同分支有望发展更为有效的骨质疏松症治疗方法。

Objective This review provides a comprehensive overview of the underlying mechanism and research findings pertaining to the STING signaling pathway in osteoporosis,aiming to offer novel insights for the therapeutic management of this condition.Methods In November 2023,the first authors searched PubMed and CNKI databases with the terms STING,osteoporosis,osteoblast,osteoclast,IFN-β,NF-κB,and type H vessels.Results A total of 41 papers were cited after screening by reading titles and abstracts.Conclusion The STING pathway provides a new direction for the treatment of osteoporosis.Activation of STING/IFN-βsignaling pathway may inhibit osteoclast differentiation and bone resorption.However,STING/NF-κB signaling may lead to an increased bone resorption and a decreased bone formation.In addition,activation of STING signaling inhibits the generation of type H vessels with osteogenic capacity,thereby inhibiting bone formation.Therefore,the STING pathway has a dual regulatory role in the progression of osteoporosis.Regulating different branches of the STING pathway is expected to develop more effective treatments for osteoporosis.