摘要
作为一种气体信号分子,近年来硫化氢(H_(2)S)防治骨质疏松的作用得到证实,其病理生理机制也陆续被阐明。H_(2)S能通过拮抗氧化应激和炎症反应、促进血管生成、调节肠道菌群和钙磷代谢,促进骨形成、抑制骨吸收,进而防治多种类型的骨质疏松,如绝经后骨质疏松、糖皮质激素或高同型半胱氨酸引发的骨质疏松。本文对现有研究进行总结,为进一步探索骨质疏松症的发病机制和治疗方案提供新思路。
As a gasotransmitter,the role of hydrogen sulfide(H_(2)S)in preventing and treating osteoporosis has been confirmed in recent years,and its pathophysiological mechanism is gradually elucidated.H_(2)S counteracts oxidative stress and inflammatory reactions,promotes angiogenesis,regulates intestinal flora and calcium-phosphorus metabolism,thus enhancing bone formation and inhibiting bone resorption,further preventing and treating various types of osteoporosis,such as postmenopausal osteoporosis and,glucocorticoid,or homocysteine-induced osteoporosis.This article summarizes the existing research to provide new insights for further understanding the pathogenesis and treatment of osteoporosis.
作者
张康华
廖锋
ZHANG Kanghua;LIAO Feng(Department of Orthopedics,Sichuan Provincial People’s Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610072,China;School of Medicine,University of Electronic Science and Technology of China,Chengdu 611731,China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2024年第11期1711-1716,共6页
Chinese Journal of Osteoporosis
基金
国家自然科学基金青年科学基金项目(82000835)。
关键词
硫化氢
骨质疏松
氧化应激
炎症反应
血管生成
肠道菌群紊乱
钙磷代谢
hydrogen sulfide
osteoporosis:oxidative stress
inflammatory reaction
angiogenesis
intestinal flora disorder
calcium and phosphorus metabolism
