雷公藤生殖及肝肾毒理机制研究进展

Research progress in reproductive and hepatorenal toxicological mechanisms of Tripterygium wilfordii

雷公藤作为治疗类风湿性关节炎、系统性红斑狼疮、干燥综合征和泌尿系统疾病等的传统中药,具备祛风除湿、活血通络、消肿止痛、杀虫解毒等多种功效,但其对生殖系统、肝脏和肾脏的毒性反应,制约了雷公藤的临床应用。本文通过查阅文献,分析雷公藤及主要活性成分(雷公藤多苷和雷公藤甲素)的毒理学机制,发现雷公藤通过诱导线粒体缺陷和凋亡、促进氧化应激和炎症反应、激活自噬和铁死亡、诱导代谢紊乱等机制,导致对生殖系统、肝脏和肾脏的毒性反应,以期为雷公藤的毒理学研究和临床应用提供参考。

Tripterygium wilfordii(TW)is a traditional Chinese medicine for treating rheumatoid arthritis,systemic lupus erythematosus,Sjogren’s syndrome,and urinary system diseases.TW has such effects as dispelling wind and dampness,promoting blood circulation and unblocking collaterals,reducing swelling and pain,killing insects and detoxification.However,the toxic reactions to the reproductive system,liver,and kidney pose a huge obstacle to TW’s clinical applications.Based on literature published over the past 3 to 5 years,the toxicological mechanisms of TW and its active ingredients(Tripterygium glycosides and Triptolide)were analyzed.TW was found to induce mitochondrial defects and apoptosis,promote oxidative stress and inflammatory reactions,activate autophagy and ferroptosis,induce metabolic disorders,and cause toxic reactions to the reproductive system,liver,and kidney.This article is expected to provide references for the toxicological research and clinical applications of TW.