终末期肾脏病相关性皮肤瘙痒发病机制的研究进展

Research progress on pathogenesis of end-stage renal disease related skin pruritus

瘙痒是终末期肾脏病患者的常见症状,高达80%接受血液透析的终末期肾脏病患者会受到瘙痒的困扰,其中40%的患者出现中度至重度瘙痒,引起睡眠不佳、抑郁、工作干扰、整体生活质量下降和死亡风险增加。然而,目前临床对终末期肾脏病相关性皮肤瘙痒认知尚不充分,缺乏有效的理论揭示其发病机制。该文总结了有关该病发病机制的最新研究进展,以期为临床诊疗提供新思路。

Pruritus is a common symptom in the patients with end-stage renal disease,up to 80%of the patients receiving hemodialysis suffer from pruritus,40%of these patients experience moderate to severe pruritus,which causes poor sleep,depression,work interference,decrease of overall quality of life and increase of death risk.However,at present,the clinical understanding of skin pruritus associated with end-stage kidney disease is not sufficient,and there is a lack of effective theories to reveal its pathogenesis.This article summarizes the latest research progress on the pathogenesis of this disease,hoping to provide the new ideas for clinical diagnosis and treatment.