内侧前额叶皮质各层结构在全身麻醉作用机制中的研究进展

Research progress in the role of the medial prefrontal cortex layered structure in general anesthesia

内侧前额叶皮质参与了各种高级脑功能,包括注意力、意识转换和信息整合,被认为既是自下而上逐层传递信息模式的终点,又是从上至下整合信息传递的起点,可能是全身麻醉药发挥意识调控作用的核心区域。内侧前额叶皮质在垂直方向上可以分为6层,层与层之间在结构上具有丰富的环路连接,每一层都有着独特的功能。在本综述中,首先描述了内侧前额叶皮质的分层结构,其次,讨论了内侧前额叶皮质各层结构在全身麻醉中的作用。为此,本文回顾了啮齿类动物、灵长类动物和人类的内侧前额叶皮质分层与麻醉的相关研究,以期望为深入了解内侧前额叶皮质在全身麻醉中的作用机制提供一定的参考。

The medial prefrontal cortex engages in various higher brain functions,including attention,transition of consciousness,and information integration,and is the central structure for the action of general anesthetics.In addition,it is considered both the end point for the bottom-up model of the layer-by-layer transmission of information and the starting point for the top-down modulation and integration of information.Classically,the medial prefrontal cortex can be divided into six layers of different functions in the vertical direction,and there are rich neural connections among the layers.In this review,we describe the laminar flow structures found in the medial prefrontal cortex,then discuss how general anesthetics change consciousness via the cortical laminar flow structures.To this aim,the article reviews the available evidence from current studies using rodents,primates,and human subjects that highlight the role of the medial prefrontal cortex in anesthesia.