单细胞测序技术在多发性硬化研究中的应用进展

Research progress in the application of single-cell sequencing technology in multiple sclerosis

多发性硬化症是一种以神经炎症和神经变性为特征的慢性中枢神经系统自身免疫性疾病,发病机制复杂,由多种中枢神经系统和外周来源的细胞参与其中。最近,单细胞测序技术逐渐应用于神经系统疾病中,对于理解细胞间异质性、疾病发展机制和治疗策略有重要意义。本文对单细胞测序技术在多发性硬化疾病中应用进展进行综述。

Multiple sclerosis(MS)is a chronic autoimmune disease of the central nervous system characterized by neuroinflammation and neurodegeneration.The pathogenesis of the disease is complex,and involves various central nervous system and peripheral cells.Single-cell sequencing has recently been increasingly applied in the study of neurological disorders,leading to important advances in our understanding of intercellular heterogeneity,disease development mechanisms,and treatment strategies.This review summarizes research progress in single-cell sequencing and its applications in MS.