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睡眠剥夺导致的损伤及益生菌缓解其损伤的研究进展

Research Progress on Sleep Deprivation Induced Damage and Probiotics to Alleviate the Damage
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摘要 睡眠是一种调节机体新陈代谢的重要生理功能。如果人们受多种因素影响减少睡眠、改变睡眠模式导致睡眠被剥夺,就会引起压力、焦虑、抑郁和认知功能下降,进而影响身心健康。反之,这些情况又会加重睡眠障碍。在睡眠剥夺情况日益严重的背景下,文章将对睡眠剥夺介导的相关疾病展开综述,并归纳总结当前缓解睡眠剥夺所致损伤的方法,包括常规精神类药物、激素类物质、生物活性物质等。研究发现,肠道是治疗睡眠剥夺相关损伤的重要靶点,而益生菌则可以通过提高肠道菌群丰富度和多样性,或者借助其产生的代谢物质来缓解睡眠剥夺造成的损伤,在睡眠剥夺损伤的治疗中具有广阔的应用前景。 Sleep is an important physiological function that regulates body metabolism.Reduced sleep and altered sleep patterns for various reasons can lead to sleep deprivation,which can cause stress,anxiety,depression,and cognitive decline,and then affect physical and mental health.Conversely,these situations can exacerbate sleep disorders.In the background of the increasingly serious sleep deprivation,the paper reviews the related diseases mediated by sleep deprivation,and summarizes the current methods to alleviate the damage caused by sleep deprivation,including conventional psychiatric drugs,hormone substance and bioactive substances.It found that the gut is an important target for the treatment of sleep deprivation related injuries,and probiotics can alleviate the damage caused by sleep deprivation by enhancing the richness and diversity of intestinal flora,or the metabolic substances produced by themselves.Therefore,probiotics have a wide application prospects in the treatment of sleep deprivation damage.
作者 谢娟 艾连中 沈闻悦 陈万旭 叶育鑫 夏永军 XIE Juan;AI Lianzhong;SHEN Wenyue;CHEN Wanxu;YE Yuxin;XIA Yongjun(School of Science Health and Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China)
出处 《工业微生物》 CAS 2024年第5期56-64,149,共10页 Industrial Microbiology
基金 国家重点研发计划(2022YFD2100702) 国家自然科学基金资助项目(32272364) 国家杰出青年科学基金(32025029) 上海市教育委员会科研创新计划项目(2101070007800120) 上海食品微生物工程技术研究中心(19DZ2281100)。
关键词 益生菌 睡眠剥夺 肠道菌群 微生物群-肠-脑轴 probiotics sleep deprivation gut microbiota microbiome-gut-brain axis
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