基于肠道微生物的肿瘤发生机制及其治疗

Tumor Pathogenesis and Treatment Based on Gut Microbiota

肠道微生物可以通过调节免疫反应、影响代谢途径、直接作用于肿瘤细胞等方式来影响宿主的生理和病理过程。这些微生物的作用已被证实与多种癌症的发生、发展密切相关,特别是在结直肠癌、胃癌和胰腺癌等消化系统肿瘤方面。文章将从肠道微生物与肿瘤发生机制的相关理论基础、不同肿瘤类型与特定肠道微生物的关联,以及微生物介导的肿瘤治疗策略等方面展开详细探讨,以期揭示肠道微生物如何通过不同生物学途径作用于肿瘤的发生、发展,从而为肿瘤的未来治疗提供新的视角和策略。

Gut microbiota can affect the physiological and pathological processes of the hosts by regulating immune response,influencing metabolic pathways,and directly interacting with tumor cells.The role of these microorganisms has been confirmed to be closely related to the occurrence and development of a variety of cancers,especially in colorectal cancer,gastric cancer,pancreatic cancer and other digestive system tumors.The article provides a detailed discussion on the theoretical basis of gut microbiota and tumor pathogenesis,the correlation between different tumor types and specific gut microbiota,and tumor treatment strategies based on microbial regulation,aiming at revealing how gut microbiota interact with tumor occurrence and development through different biological pathways,and providing new perspectives and strategies for future cancer treatment.