依达拉奉右莰醇联合灯盏花素、阿托伐他汀改善急性缺血性脑卒中患者神经功能、颈动脉粥样硬化斑块、血管内皮功能的临床效果

Clinical Effect of Edaravone Dextrocamphorol Combined with Breviscapine and Atorvastatin on Improving Nerve Function,Carotid Atherosclerotic Plaque and Vascular Endothelial Function in Patients with Acute Ischemic Stroke

目的探讨急性缺血性脑卒中患者采用依达拉奉右莰醇注射用浓溶液联合灯盏花素、阿托伐他汀治疗的应用效果。方法采用前瞻性随机抽样方法选取2023年6月—2024年6月苏州市广慈肿瘤医院收治的120例急性缺血性脑卒中患者为研究对象,按治疗方法不同分为对照组、研究组,各60例,对照组采取灯盏花素、阿托伐他汀治疗方法,研究组在对照组基础上联合依达拉奉右莰醇注射用浓溶液治疗。比较两组治疗效果、神经功能、颈动脉内膜中层厚度(intima-media thickness,IMT)、斑块面积内皮素(endothelin,ET)、血栓素B2(thromboxane B2,TXB_(2))、一氧化氮(nitric oxide,NO)、6-酮-前列腺素F1a(6-keto-PGF1a)。结果研究组总有效率为88.33%(53/60),高于对照组的73.33%(44/60),差异有统计学意义(χ^(2)=4.357,P<0.05)。治疗后,研究组卒中评分、IMT厚度、斑块面积、ET、TXB2均低于对照组,NO、6-keto-PGF1a均高于对照组,差异有统计学意义(P均<0.05)。结论急性缺血性脑卒中患者采用依达拉奉右莰醇注射用浓溶液联合灯盏花素、阿托伐他汀治疗,疗效显著,可有效改善神经功能,减小IMT厚度、斑块面积,减轻血管内皮细胞损伤,对促进患者康复具有积极的意义。

Objective To investigate the therapeutic effect of edaravone dextrocamphorol injection combined with breviscapine and atorvastatin in patients with acute ischemic stroke.Methods A prospective random sampling method was used to select 120 patients with acute ischemic stroke admitted to Suzhou Guangci Tumor Hospital from June 2023 to June 2024 as the research objects.According to different treatment methods,they were divided into control group and study group,with 60 cases in each group.The control group was treated with breviscapine and atorvastatin,and the study group was treated with edaravone and right camphor alcohol injection concentrated solution on the basis of the control group.The therapeutic effect,neurological function,carotid intima-media thickness(IMT),plaque area,endothelin(ET),Thromboxane B2(TXB2),Nitric Oxide(NO),6-keto-prostaglandin F1a(6-keto-PGF1a)were compared between the two groups.Results The total effective rate of the study group was 88.33%(53/60),which was higher than 73.33%(44/60)of the control group,and the difference was statistically significant(χ^(2)=4.357,P<0.05).After treatment,stroke score,IMT thickness,plaque area,ET and TXB_(2) in the study group were lower than those in the control group,while NO and 6-keto-PGF1a were higher than those in the control group,and the differences were statistically significant(all P<0.05).Conclusion Acute ischemic stroke patients were treated with concentrated solution of edaravone dextrocamphorol injection combined with breviscapine and atorvastatin,which has significant curative effect,can effectively improve nerve function,reduce IMT thickness and plaque area,and reduce damage to vascular endothelial cells,which has positive significance for promoting rehabilitation of patients.