四联疗法根除幽门螺杆菌10 d疗程和14 d疗程的对比研究

Comparative Study of 10-day and 14-day Quadruple Therapy for the Eradication of Helicobacter Pylori

目的:探讨艾司奥美拉唑肠溶胶囊+胶体果胶铋+多西环素+克拉霉素四联疗法的10 d疗程与14 d疗程对根除幽门螺杆菌的治疗效果。方法:选取于2021年3月~2024年3月在河池市第三人民医院确诊为幽门螺杆菌感染且对阿莫西林过敏、采用四联疗法(艾司奥美拉唑肠溶胶囊+胶体果胶铋+多西环素+克拉霉素)治疗的患者,按照疗程不同分为10 d疗程组和14 d疗程组。收集两组患者资料,对两组患者的幽门螺杆菌的根除率、不良反应以及治疗成本进行比较。结果:10 d疗程组和14 d疗程组的幽门螺杆菌根除率、不良反应率比较差异无统计学意义(P>0.05)。10 d疗程组的治疗费用明显低于14 d疗程组,差异有统计学意义(P<0.05)。结论:10 d疗程与14 d疗程均能达到根除Hp的治疗效果,从时间和治疗成本考虑,前者更值得临床推广。

Objective To explore the efficacy of a 10-day versus a 14-day course of quadruple therapy with Esomeprazole Enteric Capsules,Colloidal Bismuth Pectin,Doxycycline,and Clarithromycin for the eradication of Helicobacter pylori(Hp).Method Patients diagnosed with Hp infection who were allergic to Amoxicillin and treated with quadruple therapy(Esomeprazole Enteric Capsules,Colloidal Bismuth Pectin,Doxycycline,and Clarithromycin)at Hechi Third People's Hospital between March 2021 and March 2024 were selected for the study.Based on treatment duration,patients were divided into a 10-day course group and a 14-day course group.Data on the eradication rates of Hp,adverse reactions,and treatment costs were collected and compared between the two groups.Results The difference in eradication rates and adverse reactions between the 10-day and 14-day groups was not statistically significant(P>0.05).The treatment cost for the 10-day course group was significantly lower than that for the 14-day course group,with a statistically significant difference(P<0.05).Conclusion Both the 10-day and 14-day courses of therapy achieve effective eradication of Hp.Considering time and treatment costs,the 10-day course is more suitable for clinical promotion.