基于ICP-MS法的狗脊重金属含量测定

Determination of Heavy Metal Content in Cibotium Barometz Based on ICP-MS Method

采用电感耦合等离子体质谱(ICP-MS)法测定狗脊中重金属元素的含量。狗脊样品经过微波消解后,以锗、铟、铋为内标,测试了铜(Cu)、铅(Pb)、砷(As)、镉(Cd)、汞(Hg)5种重金属元素含量。研究结果表明,样品中均检测到了Pb、As、Cd、Hg和Cu 5种重金属元素,且元素测试线性关系良好(r≥0.9992),RSD范围为2.2%~5.4%。药材中5种重金属元素含量均在国家药典标准要求范围内。建议增加药典中狗脊重金属元素含量的检查项,完善其质量控制方法。

Inductively coupled plasma mass spectrometry(ICP-MS)was used to determine the content of harmful heavy metal elements in traditional Chinese medicine Cibotium barometz.After microwave digestion of traditional Chinese medicine samples,the contents of five heavy metal elements,copper(Cu),lead(Pb),arsenic(As),cadmium(Cd),and mercury(Hg),were tested using germanium,indium,and bismuth as internal standards.The research results indicate that five heavy metal elements(Pb As,Cd,Hg,and Cu)were detected in all samples and the linear relationship between element testing is good(r≥0.9992).The RSD range is 2.2%to 5.4%.The content of five heavy metal elements in the medicinal herbs is within the range required by the national pharmacopoeia standards.It is suggested to add inspection items for the content of heavy metal elements in Cibotium barometz in the pharmacopoeia and improving its quality control methods.