青少年抑郁障碍脑结构影像研究进展

Research progress on brain structural imaging in adolescents with depressive disorders

青少年抑郁障碍患病率逐年增加,不仅影响着青少年的心理健康发展,也给家庭和社会带来了严重的负担。目前,抑郁障碍的病因尚不明确,其诊断主要依靠症状学表现,缺乏客观依据。磁共振成像(MRI)等脑影像学技术被广泛应用以探索抑郁障碍相关的神经生物标志物,其对疾病的早期发现、诊断、治疗以及判断预后、预测治疗反应等具有重要意义。本文对近年来青少年抑郁障碍患者脑结构影像学方面的相关研究进行综述。

The incidence of depressive disorder in adolescents is increasing year by year,which not only affects their mental health development,but also brings serious burdens to families and society.At present,the etiology of depressive disorder is not yet clear,and its diagnosis mainly relies on symptomatology,lacking objective basis.Magnetic resonance imaging(MRI)and other brain imaging techniques are widely used to explore neurobiological markers related to depressive disorder,which are of great significance for early detection,diagnosis,treatment,prognosis,and treatment response prediction of diseases.This paper reviews the research on brain structural imaging of adolescents with depressive disorders in recent years.