多囊卵巢综合征伴焦虑、抑郁障碍的相关性研究

Research on the Correlation between Polycystic Ovary Syndrome and Anxiety and Depression Disorders

多囊卵巢综合征(polycystic ovary syndrome,PCOS)是一种育龄期女性常见的生殖内分泌代谢性疾病。临床上PCOS伴随的一系列症状给患者带来巨大的身心负担,如肥胖、痤疮、多毛、黑棘皮等颜面躯体症状,稀发排卵、月经紊乱甚至不孕等生殖问题,胰岛素抵抗、高雄激素血症等代谢紊乱。与正常人群相比,PCOS患者更易产生负性情绪,发生情绪障碍,其中最常见的就是焦虑和抑郁障碍。流行病学研究显示,PCOS患者高发焦虑、抑郁障碍。此外,越来越多的证据显示,PCOS与焦虑、抑郁障碍在发病机制方面联系密切,有众多相似的临床表现或致病因素,PCOS与焦虑、抑郁障碍常互为因果、互相影响,形成恶性循环。故呼吁对PCOS患者的负性情绪进行早期识别和干预。

Polycystic ovary syndrome(PCOS)is a common reproductive endocrine and metabolic disease in women of childbearing age.Clinically,it is accompanied by a series of facial and physical symptoms such as obesity,acne,hirsutism and black skin,reproductive problems such as infrequent ovulation,menstrual disorders and even infertility,and metabolic disorders such as insulin resistance and hyperandrogenism.Compared with the normal population,PCOS patients are more prone to negative emotions and emotional disorders,with anxiety and depression disorders being the most common.Epidemiological studies have shown that anxiety and depression disorders are highly prevalent in patients with PCOS.In addition,increasing evidence suggests that PCOS is closely related to anxiety and depression disorders in terms of pathogenesis,with many similar clinical manifestations or pathogenic factors.PCOS often has a causal relationship and mutual influence with anxiety and depression disorders,forming a vicious cycle.Therefore,it is called for early identification and intervention of negative emotions in PCOS patients.