加味白头翁灌肠方治疗难治性放射性肠炎的疗效及对患者血清胰高血糖素样肽-2白细胞介素-17水平的影响

Effects of supplemented modified Baitouweng Anemone Enema in the treatment of refractory radiation enteritis and its impact on serum GLP-2 and IL-17 levels

目的探究加味白头翁保留灌肠对难治性放射性肠炎的疗效及对患者血清胰高血糖素样肽-2(GLP-2)、白细胞介素(IL)-17水平的影响。方法按照不同治疗方法将2022年1月至2023年12月在浙江省金华市中心医院放疗科收治的80例难治性放射性肠炎患者分为对照组和干预组,每组各40例。对照组予常规治疗,干预组采用加味白头翁保留灌肠的干预方法,治疗时间共7 d。比较2组治疗后症状改善情况及治疗前后肠道欧洲癌症治疗研究组织(EORTC)分级、中医证候量表评分、血清胰高血糖素样肽-2(GLP-2)、白细胞介素-17(IL-17)水平。结果干预组症状总缓解率97.5%高于对照组95.0%,差异有统计学意义(P<0.05);治疗后EORTC分级较治疗前好转(P<0.05),干预组优于对照组(P<0.05);对照组治疗后中医证候评分[8(1.5,10)]分低于治疗前[10(10,14)分],干预组治疗后中医证候评分[6(0,8)分]低于治疗前[12(8,14)分],且干预组低于对照组(P<0.05);2组GLP-2水平较治疗前升高,IL-17水平较治疗前降低,干预组优于对照组(P<0.05)。结论加味白头翁灌肠治疗难治性放射性肠炎效果明显,能修复肠黏膜损伤,减轻症状,改善血清GLP-2和IL-17水平。

ObjectiveTo explore the effects of supplemented modified Baitouweng Anemone Enema in the treatment of refractory radiation enteritis and its impact on serum GLP-2 and IL-17 levels.MethodsA total of 80 patients with refractory radiation enteritis who were admitted to the Jinhua Central Hospital from January 2022 to December 2023 were selected and divided into a control group and an intervention group,with 40 cases in each group according to treatment methods.The control group received conventional treatment,while the intervention group underwent modified Baitouweng anemone enema.Both groups received treatment for a total of 7 days.The improvement of symptoms,intestinal EORTC grading,Traditional Chinese Medicine Syndrome Scale score,serum glucagon like peptide-2(GLP-2),and interleukin-17(IL-17)levels before and after treatment were compared between the two groups.ResultsThe total symptom relief rate of the intervention group(97.5%)was higher than that of the control group(95.0%),and the difference was statistically significant(P<0.05).After treatment,the EORTC grading improved compared to before treatment(P<0.05),and the intervention group was better than the control group(P<0.05).The TCM symptom score of the control group after treatment[8(1.5,10)points]was lower than that before treatment[10(10,14)points].After treatment,the TCM symptom score of the in-tervention group[6(0,8)points]was lower than before treatment[12(8,14)points],and the intervention group was lower than the control group(P<0.05).The levels of GLP-2 in both groups increased compared to before treatment,but the levels of IL-17 decreased compared to before treatment,and the intervention group was better than the control group(P<0.05).ConclusionThe modified Baitouweng Anemone Enema has a significant effect on the in-tervention of refractory radiation enteritis,which can repair intestinal mucosal damage,alleviate symptoms,and improve serum GLP-2 and IL-17 levels.