鼻咽癌组织中NK-1R、CXCL10、VEGFR-2、PDK1表达对患者预后的评估价值

Evaluation Value of Expression of NK-1R,CXCL10,VEGFR-2 and PDK1 in Nasopharyngeal Carcinoma in Patients with Prognosis

目的分析鼻咽癌组织中神经激肽-1(NK-1R)、趋化因子配体10(CXCL10)、血管内皮生长因子受体2(VEGFR-2)、丙酮酸脱氢酶激酶1(PDK1)对患者预后的评估价值。方法选取137例鼻咽癌患者,对患者鼻咽癌组织、癌旁组织中NK-1R、CXCL10、VEGFR-2、PDK1表达进行检测,治疗后随访1年,根据复发转移情况评估患者预后并分为预后良好组(无复发转移)、预后不良组(复发转移),比较2组鼻咽癌组织中NK-1R、CXCL10、VEGFR-2、PDK1表达,分析鼻咽癌组织中NK-1R、CXCL10、VEGFR-2、PDK1对评估患者预后的价值。结果鼻咽癌组织中NK-1R、CXCL10、VEGFR-2、PDK1阳性表达率高于癌旁组织,差异有统计学意义(P<0.05);137例鼻咽癌患者治疗后随访1年发现,有39例复发转移,预后不良发生率为28.47%(39/137)。预后不良组NK-1R、CXCL10、VEGFR-2、PDK1阳性率高于预后良好组,差异有统计学意义(P<0.05)。绘制ROC曲线发现,鼻咽癌组织中NK-1R、CXCL10、VEGFR-2、PDK1表达评估患者预后的AUC分别为0.713、0.706、0.714、0.719,均有一定评估价值。结论鼻咽癌组织中NK-1R、CXCL10、VEGFR-2、PDK1与患者预后有关,可为预后评估提供参考。

Objective To evaluate the prognostic value of neurokinin-1(NK-1R),chemokine ligand 10(CXCL10),vascular endothelial growth factor receptor 2(VEGFR-2)and pyruvate dehydrogenase kinase 1(PDK1)in nasopharyngeal carcinoma.Methods 137 patients with nasopharyngeal carcinoma were selected to detect the expression of NK-1R,CXCL10,VEGFR-2 and PDK1 in nasopharyngeal carcinoma tissues and adjacent tissues.The patients were followed up for 1 year after treatment to evaluate the prognosis and divided into good prognosis group(no recurrence and metastasis)and poor prognosis group(recurrence and metastasis)according to the recurrence and metastasis.The expressions of NK-1R,CXCL10,VEGFR-2 and PDK1 in nasopharyngeal carcinoma tissues of the 2 groups were compared,and the value of NK-1R,CXCL10,VEGFR-2 and PDK1 in evaluating the prognosis of patients was analyzed.Results The positive expression rates of NK-1R,CXCL10,VEGFR-2 and PDK1 in nasopharyngeal carcinoma tissues were higher than those in adjacent tissues,and the difference was statistically significant(P<0.05).In 137 patients with nasopharyngeal carcinoma followed up for 1 year after treatment,39 cases had recurrence and metastasis,and the incidence of poor prognosis was 28.47%(39/137).The positive rates of NK-1R,CXCL10,VEGFR-2 and PDK1 in the poor prognosis group were higher than those in the good prognosis group,and the difference was statistically significant(P<0.05).The ROC curve showed that the AUC of NK-1R,CXCL10,VEGFR-2 and PDK1 expression in nasopharyngeal carcinoma tissue to evaluate the prognosis of patients was 0.713,0.706,0.714 and 0.719,respectively,all of which had certain evaluation value.Conclusion NK-1R,CXCL10,VEGFR-2 and PDK1 in nasopharyngeal carcinoma are related to the prognosis of patients,which can provide reference for prognosis evaluation.