CO_(2)激光联合低温等离子射频消融术对早期声门型喉癌患者的疗效分析

Effect of CO_(2)Laser Combined with Low-temperature Plasma Radiofrequency Ablation on Patients with Early Glottic Carcinoma

目的探讨CO_(2)激光联合低温等离子射频消融术(LTPRFA)治疗早期声门型喉癌(EGC)患者的临床效果。方法收治EGC患者80例,按随机数字表法分为2组。对照组(n=40)采取喉部分切开手术治疗,观察组(n=40)采用CO_(2)激光联合LTPRFA治疗。比较两组临床疗效、嗓音功能、疼痛程度[视觉模拟评分法(VAS)]、声带形态学评分及复发率。结果观察组临床疗效(87.50%)高于对照组(60.00%);治疗后观察组振幅微扰(2.68±0.41)%、基频微扰(1.16±0.14)%及基频(137.82±5.43)Hz均低于对照组,谐噪比(23.14±3.41)dB高于对照组,VAS评分(2.07±0.15)分低于对照组,声带形态学评分(1.14±0.12)分低于对照组,复发率(5.00%)低于对照组(22.50%),差异有统计学意义(P<0.05)。结论EGC患者采用LTPRFA治疗可取得显著疗效,利于嗓音功能恢复,减轻疼痛程度,改善声带形态学,并降低复发率。

Objective To explore the clinical effect of CO_(2)laser combined with low-temperature plasma radiofrequency ablation(LTPRFA)in treating patients with early glottic laryngeal cancer(EGC).Methods 80 patients with EGC were randomly divided into 2 groups.The control group(n=40)was treated with partial laryngectomy,while the observation group(n=40)was treated with CO_(2)laser combined with LTPRFA.The clinical efficacy,voice function,pain degree[visual analogue scale(VAS)],vocal cord morphology score and recurrence rate were compared between the 2 groups.Results The clinical efficacy of the observation group(87.50%)was higher than that of the control group(60.00%).After treatment,the amplitude perturbation(2.68±0.41)%,fundamental frequency perturbation(1.16±0.14)%,and fundamental frequency(137.82±5.43)Hz of the observation group were lower than those of the control group,and the harmonic to noise ratio(23.14±3.41)dB was higher than that of the control group,and the VAS score(2.07±0.15)score was lower than that of the control group,vocal fold morphology score(1.14±0.12)score was lower than that of the control group,and the recurrence rate(5.00%)was lower than that of the control group(22.50%),and the difference was statistically significant(P<0.05).Conclusion The treatment of EGC patients with LTPRFA can achieve significant efficacy,facilitate the recovery of voice function,reduce the degree of pain,improve the morphology of the vocal folds,and reduce the recurrence rate.