血清IL-23、HE4水平变化与宫颈癌发生发展的关系

Relationship Between Changes in Serum IL-23 and HE4 Levels and the Development of Cervical Cancer

目的探究血清白细胞介素(IL)-23、人附睾分泌蛋白(HE4)水平变化与宫颈癌发生发展的关系。方法选取宫颈癌患者90例作为宫颈癌组,以同期收治的宫颈上皮内瘤变患者90例和健康体检者90例分别作为良性肿瘤组和健康对照组。分别采用ELISA法、电化学发光法检测3组人群血清中IL-23、HE4水平,并分析其与宫颈癌患者临床参数的关系。对宫颈癌患者进行定期随访,随访终点为全因死亡。根据随访结果将其分为死亡组和生存组,比较2组血清IL-23、HE4水平差异,绘制受试者工作特征(ROC)曲线,分析血清IL-23、HE4对宫颈癌患者的预后评估价值。结果相较于健康对照组,宫颈癌组、良性肿瘤组血清IL-23、HE4水平升高,其中宫颈癌组更高,差异有统计学意义(P<0.05)。不同临床分期、组织分化程度、浸润深度、淋巴结转移的宫颈癌患者血清IL-23、HE4水平比较,差异具有统计学意义(P<0.05)。随访至2023年10月1日,90例宫颈癌患者中10例死亡。死亡组血清IL-23、HE4水平高于生存组,差异有统计学意义(P<0.05)。ROC曲线显示,血清IL-23、HE4预测宫颈癌预后的AUC分别为0.723、0.720,联合检测AUC为0.859,大于二者单独检测(P<0.05)。结论血清IL-23、HE4与宫颈癌的发生发展有关,可作为患者的预后评估指标。

Objective To investigate the relationship between changes in serum interleukin(IL)-23 and human epididymal secretory protein(HE4)levels and the development of cervical cancer.Methods 90 patients with cervical cancer were selected as the cervical cancer group,and 90 patients with cervical intraepithelial neoplasia and 90 healthy medical check-ups admitted during the same period were used as the benign tumour group and healthy control group,respectively.Serum IL-23 and HE4 levels were detected by ELISA and electrochemiluminescence in the 3 groups,respectively,and their relationships with clinical parameters of cervical cancer patients were analyzed.Patients with cervical cancer were followed up regularly,and the follow-up endpoint was all-cause death.According to the follow-up results,they were divided into the death group and the survival group,and the differences in serum IL-23 and HE4 levels between the 2 groups were compared,and the working characteristics(ROC)curves of the subjects were plotted,so as to analyse the prognostic assessment value of serum IL-23 and HE4 for patients with cervical cancer.Results Compared with the healthy control group,serum IL-23 and HE4 levels were elevated in the cervical cancer group and benign tumour group,which were higher in the cervical cancer group,and the difference was statistically significant(P<0.05).Comparison of serum IL-23 and HE4 levels in cervical cancer patients with different clinical stages,tissue differentiation degree,infiltration depth and lymphatic metastasis showed statistically significant differences(P<0.05).Follow-up to 1 October 2023,10 of the 90 cervical cancer patients died.The serum IL-23 and HE4 levels in the death group were higher than those in the survival group,and the difference was statistically significant(P<0.05).The ROC curves showed that the AUCs of serum IL-23 and HE4 for predicting the prognosis of cervical cancer were 0.723 and 0.720,respectively,and the AUC for the combined test was 0.859,which was greater than that of the 2 alone(P<0.05).Conclusion Serum IL-23 and HE4 are related to the development of cervical cancer and can be used as prognostic assessment indicators for patients.