桑枝生物碱研究进展

Research progress of mulberry twig alkaloids

桑枝是桑科植物桑(Mrous alba L.)的干燥嫩枝,具有祛风湿、利关节等功效,在传统中医中常用于治疗风湿痹病、关节酸痛麻木等病症。现代研究发现桑枝具有多种药理作用,包括调节糖脂代谢异常、抗氧化、抗菌、抗病毒等。生物碱是桑枝中重要的活性成分,具有良好的降血糖作用,还具有调节糖脂代谢和肠道菌群、保护胰岛β细胞、改善葡萄糖刺激的胰岛素分泌功能、刺激GLP-1分泌等作用。文章通过对桑枝生物碱种类、体内合成通路、提取检测方法以及药理作用进行综述,为桑枝生物碱的深入研究及高效利用提供参考依据。

Mulberry twig is the dry twig of Mrous alba L.in Moraceae family.It can be used to treat rheumatism and numbness of joints in traditional Chinese medicine.Modern studies have found that mulberry twig has a variety of pharmacological effects,including regulation of abnormal glucose and lipid metabolism,antioxidant,antibacterial,antiviral,etc.Alkaloids are important active components in mulberry twig,which have good hypoglycemic effect.It also regulates glycolipid metabolism and intestinal microbiota,protects isletβcells,improves glucose-stimulated insulin secretion function,and stimulates GLP-1 secretion.In this paper,the types,synthetic pathways,extraction and detection methods and pharmacological effects of mulberry twig alkaloids were reviewed.This paper aims to provide reference for further study and efficient utilization of mulberry twig alkaloids.