用于乳腺癌标志物检测的自供电光电化学传感器

Self-powered Photoelectrochemical Sensors for Detection of Breast Cancer Marker

为了检测人表皮生长因子受体2,构建一种新型的自供电光电化学传感器;以铟锌硫化物、铟镁硫化物、钠离子、钾离子掺杂的亚甲基蓝(MB)敏化的碳化氮复合物ZnIn_(2)S_(4)/MgIn_(2)S_(4)/NaKC_(3)N_(4)-MB作为光电阳极,金属炔基聚合物苯基乙烯基铜(PPhECu)纳米棒作为光电阴极,采用X射线衍射、扫描电子显微镜、透射电子显微镜对复合物进行表征,并进行光电化学检测。结果表明:光活性ZnIn_(2)S_(4)/MgIn_(2)S_(4)/NaKC_(3)N_(4)-MB光电阳极中异质结构的形成加速了光生电子的转移,使其具有优异的光电性能,能够作为对电极为传感系统提供电子;集成的光电阳极和光电阴极的自供电光电化学检测模式可消除生物样品中还原性物质的干扰,显著提高光电化学传感器的抗干扰能力及检测灵敏度,检测质量浓度范围为5×10^(-5)~200 mg/L,检测限为0.0156 ng/L。

To detect human epidermal growth factor receptor 2(HER2),a novel self-powered photoelectrochemical(PEC)sensor was constructed.Indium-zinc sulfide,indium-m agnesium sulfide,sodium ion,and potassium ion doped methylene blue-sensitized nitrogen carbide complex ZnIn_(2)S_(4)/MgIn_(2)S_(4)/NaKC_(3)N_(4)-MB was used as the photoelectrocathode,and the metal alkyne polymer phenyl vinyl copper(PPhECu)nanorods was used as photocathode,the complexes were characterized by X-ray diffraction,scanning electron microscopy,transmission electron microscopy,and photo-and electrochemical detection.The results show that the formation of heterostructures in the photoactive ZnIn_(2)S_(4)/MgIn_(2)S_(4)/NaKC_(3)N_(4)-MB photoanode accelerates the transfer of photogenerated electrons,which results in excellent photovoltaic performance,and can be used as a counter electrode to provide electrons for the sensing system.The self-powered PEC detection mode of the integrated photo-anode and photocathode can eliminate the interference of reducing substances in biological samples,which significantly improves the anti-interference ability and detection sensitivity of the PEC sensor,and detects the mass concentration in the range of 5×10^(-5)~200 mg/L with the detection limit of 0.0156 ng/L.