甲硝唑、多西环素与头孢曲松联合治疗对盆腔炎患者炎症反应及血液流变学的影响

Effects of Metronidazole,Doxycycline Combined with Ceftriaxone on Inflammatory Response and Hemorheology in Patients with Pelvic Inflammatory Disease

目的分析甲硝唑、多西环素与头孢曲松联合治疗对盆腔炎患者炎症反应与血液流变学的影响。方法随机选取2020年10月—2022年6月枣庄市市中区妇幼保健院收治的90例盆腔炎患者为研究对象,根据不同治疗方法分为研究组与对照组,对照组使用多西环素与头孢曲松治疗,研究组加用甲硝唑治疗。比较两组患者的炎症反应、血液流变学、血流动力学及治疗效果。结果治疗后,研究组炎性因子水平优于对照组,差异有统计学意义(P<0.05)。治疗后,研究组的血液流变学和血流动力学指标均优于对照组,差异有统计学意义(P均<0.05)。研究组治疗总有效率为95.56%(43/45),高于对照组的80.00%(36/45),差异有统计学意义(χ^(2)=5.075,P<0.05)。结论盆腔炎患者采用甲硝唑、多西环素与头孢曲松治疗,有助于消解患者机体的炎症反应,改善其血液流变学,提升疗效。

Objective The effects of metronidazole,doxycycline and ceftriaxone on inflammatory response and hemorheology in patients with pelvic inflammatory disease were analyzed.Methods A total of 90 patients with pelvic inflammatory disease admitted to Zaozhuang Shizhong District Maternal and Child Health Hospital from October 2020 to June 2022 were randomly selected as the research objects.According to different treatment methods,they were divided into study group and control group.The control group was treated with doxycycline and ceftriaxone,and the study group was treated with metronidazole additionally.The inflammatory response,hemorheology,hemodynamics and therapeutic effect were compared between the two groups.Results After treatment,the level of inflammatory factors in the study group was better than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the indexes of hemorheology and hemodynamics in the study group were better than those in the control group,and the differences were statistically significant(both P<0.05).The total effective rate of treatment in the study group was 95.56%(43/45),which was higher than 80.00%(36/45)in the control group,and the difference was statistically significant(χ^(2)=5.075,P<0.05).Conclusion The treatment of metronidazole,doxycycline and ceftriaxone in patients with pelvic inflammatory disease is helpful to eliminate the inflammatory reaction of the patient's body,improve its hemorheology and improve the curative effect.