复发性卵巢癌患者预后的危险因素分析

Analysis of Prognostic Risk Factors in Patients with Recurrent Ovarian Cancer

目的 分析复发性卵巢癌患者的预后以及危险因素,为卵巢癌的临床治疗及预后提供参考依据。方法回顾性选取2017年1月—2023年1月淮安市第一人民医院收治的40例复发性卵巢癌患者的临床资料,依据预后情况分为存活组(15例)和死亡组(25例),分析患者生存率、死亡率及影响预后生存的相关危险因素。结果 40例复发性卵巢癌患者,15例存活,生存率为37.50%,死亡25例,死亡率为62.50%。两组患者复发伴腹水、二次肿瘤细胞减灭术、靶向药物的使用与化疗疗程等因素比较,差异有统计学意义(P均<0.05)。复发伴腹水(OR=6.472,95%CI:3.161~13.249)与化疗疗程<6次(OR=3.288,95%CI:1.595~6.776)均为复发性卵巢癌患者影响预后生存时间的独立危险因素(P均<0.05),而二次肿瘤细胞减灭术(OR=0.297,95%CI:0.154~0.573)以及靶向药物的使用(OR=0.136,95%CI:0.097~0.630)均为影响生存时间的保护因素(P均<0.05)。结论复发性卵巢癌患者生存期较短,且预后较差,复发伴腹水与化疗疗程<6次均为影响复发性卵巢癌患者预后的独立危险因素。而二次肿瘤细胞减灭术以及靶向药物的使用均为影响患者预后生存时间的保护因素,临床应结合患者的自身状况,合理规范化的制订化疗方案,尽可能的延长患者生存期。

Objective To analyze the prognosis and risk factors of patients with recurrent ovarian cancer,and to pro⁃vide reference for the clinical treatment and prognosis of ovarian cancer.Methods Clinical data of 40 patients with re⁃current ovarian cancer admitted to Huai'an First People's Hospital from January 2017 to January 2023 were retro⁃spectively selected,and were divided into survival group(15 cases)and death group(25 cases)according to prognosis.The survival rate,mortality rate and related risk factors affecting prognosis and survival of the two groups were ana⁃lyzed.Results Of 40 patients with recurrent ovarian cancer,15 survived,the survival rate was 37.50%,25 died,the mortality rate was 62.50%.There were statistically significant differences in recurrence with ascites,secondary tumor cell reduction,the use of targeted drugs and the duration of chemotherapy between the two groups(all P<0.05).Recur⁃rence with ascites(OR=6.472,95%CI:3.161~13.249)and chemotherapy duration<6 times(OR=3.288,95%CI:1.595~6.776)were independent risk factors affecting the survival time of patients with recurrent ovarian cancer(both P<0.05),while secondary tumor cell reduction(OR=0.297,95%CI:0.154~0.573)and the use of targeted drugs(OR=0.136,95%CI:0.097~0.630)were protective factors affecting survival time(both P<0.05).Conclusion The survival time of patients with recurrent ovarian cancer is short and the prognosis is poor.Recurrence with ascites and chemo⁃therapy course<6 times are independent risk factors affecting the prognosis of patients with recurrent ovarian cancer,while secondary tumor cell reduction and the use of targeted drugs are protective factors affecting the prognosis and survival time of patients.Clinical treatment should be combined with patients'own conditions.Reasonable and stan⁃dardized formulation of chemotherapy regimen,as far as possible to prolong the survival of patients.