芪蛭消栓汤+静脉溶栓治疗急性脑梗死的疗效

Therapeutic Effect of Qizhi Xiaoshuan Decoction Combined with Intravenous Thrombolysis on Acute Cerebral Infarction

目的分析芪蛭消栓汤+静脉溶栓治疗急性脑梗死的疗效。方法选取2023年1—11月寿光市人民医院收治的80例急性脑梗死患者为研究对象,按照治疗方法的不同分对照组、观察组,各40例。对照组行静脉溶栓治疗,观察组行芪蛭消栓汤+静脉溶栓治疗,对比两组美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分、格拉斯哥昏迷指数(Glasgow Coma Scale,GCS)、炎性因子水平、血清学指标、不良反应发生率。结果治疗前,两组NIHSS评分、GCS比较,差异无统计学意义(P均>0.05);治疗后,与对照组相比,观察组NIHSS评分较低,GCS较高,差异有统计学意义(P均<0.05)。治疗后,两组C反应蛋白、降钙素原、白细胞介素-8水平均降低,且观察组均低于对照组,差异有统计学意义(P均<0.05)。治疗后,观察组视锥蛋白样蛋白1、正五聚蛋白3、陷窝蛋白1水平均低于对照组,差异有统计学意义(P均<0.05)。观察组不良反应发生率为5.00%(2/40),与对照组的10.00%(4/40)相比,差异无统计学意义(χ^(2)=0.180,P>0.05)。结论急性脑梗死患者静脉溶栓治疗中加用芪蛭消栓汤具有强化疗效的作用,可促进神经功能性改善及降低血清学指标水平,且安全性良好。

Objective To analyze the efficacy of Qizhi Xiaoshuan Decoction+intravenous thrombolysis in the treatment of acute cerebral infarction.Methods A total of 80 patients with acute cerebral infarction admitted to Shouguang People's Hospital from January to November 2023 were selected as the research objects.According to the different treatment methods,they were divided into control group and observation group,with 40 cases in each group.The control group was treated with intravenous thrombolysis,and the observation group was treated with Qizhi Xiaoshuan Decoction+intravenous thrombolysis.The National Institute of Health Stroke Scale(NIHSS)score,Glasgow Coma Scale(GCS),inflammatory factor levels,serological indicators,and incidence of adverse reactions were compared between the two groups.Results Before treatment,there were no significant difference in NIHSS score and GCS between the two groups(both P>0.05).After treatment,compared with the control group,the NIHSS score of the observation group was lower and the GCS was higher,and the differences were statistically significant(both P<0.05).After treatment,the levels of C-reactive protein,procalcitonin,interleukin-8 in the two groups decreased,and the observation group were lower than the control group,and the differences were statistically significant(all P<0.05).After treatment,the levels of visinin-like protein 1,pentraxin 3 and caveolin-1 in the observation group were lower than those in the control group,and the differences were statistically significant(all P<0.05).The incidence of adverse reactions in the observation group was 5.00%(2/40),compared with 10.00%(4/40)in the control group,the difference was not statistically significant(χ^(2)=0.180,P>0.05).Conclusion In the intravenous thrombolytic therapy of patients with acute cerebral infarction,the addition of Qizhi Xiaoshuan Decoction has a strengthening effect,promotes neurological functional improvement and reduces the level of serological indicators,and has good safety.