胰岛素泵短期强化治疗对新发2型糖尿病患者胰岛素分泌功能的影响

Effect of Short-term Intensive Insulin Pump Therapy on Insulin Secretion Function in Patients with Newly Diagnosed Type 2 Diabetes Mellitus

目的分析新发2型糖尿病(type 2 diabetes mellitus,T2DM)患者采取胰岛素泵短期强化治疗后胰岛素分泌功能的影响。方法选取2021年1月—2024年6月临朐县中医院收治的60例新发T2DM患者为研究对象,根据不同治疗方式分为两组,各30例;对照组行胰岛素多次皮下注射治疗,观察组行胰岛素泵短期强化治疗,对比两组临床疗效、胰岛功能、血糖水平、空腹胰岛素及空腹C肽水平、血糖达标时间、不良反应发生率。结果观察组治疗有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组空腹血糖、餐后2 h血糖、空腹胰岛素及空腹C肽水平优于对照组,差异有统计学意义(P均<0.05)。观察组血糖达标时间短于对照组,差异有统计学意义(P<0.05)。治疗后,观察组胰岛β细胞功能指数高于对照组,胰岛素抵抗指数低于对照组,差异有统计学意义(P均<0.05)。观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论胰岛素泵短期强化治疗对新发T2DM具有确切疗效,可改善机体胰岛素抵抗,刺激胰岛素分泌,并提升其敏感性,促进血糖达标,安全性高。

Objective To analyze the effect of insulin secretion function in newly diagnosed type 2 diabetes mellitus(T2DM)patients after short-term intensive treatment with insulin pump.Methods From January 2021 to June 2024,60 patients with newly-diagnosed T2DM admitted to Linqu Hospital of Traditional Chinese Medicine were selected as the research objects.According to different treatment methods,they were divided into two groups,30 cases in each group.The control group was treated with multiple subcutaneous injections of insulin,and the observation group was treated with short-term intensive insulin pump.The efficacy,islet function,blood glucose levels,levels of fasting insu⁃lin and fasting C-peptide,blood glucose standard time and incidence of adverse reactions were compared between the two groups.Results The effective rate of the observation group was higher than that of the control group,and the dif⁃ference was statistically significant(P<0.05).After treatment,fasting blood glucose,2-hour postprandial blood glu⁃cose,fasting insulin and fasting C-peptide levels in the observation group were better than those in the control group,and the differences were statistically significant(all P<0.05).The blood glucose standard time in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the isletβcell function index of the observation group was higher than that of the control group,and the insulin resistance index was lower than that of the control group,the differences were statistically significant(both P<0.05).The inci⁃dence of adverse reactions in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion Shortterm intensive therapy with insulin pump has a definite effect on newly diagnosed T2DM,which can improve the body's insulin resistance,stimulate insulin secretion,enhance its sensitivity,promote blood glucose standard,and have high safety.