恩格列净联合贝那普利在糖尿病肾病患者中的治疗效果分析

Therapeutic Effect of Empagliflozin Combined with Benazepril in Patients with Diabetic Nephropathy

目的探讨恩格列净联合贝那普利在糖尿病肾病患者治疗中的效果。方法回顾性选取2023年6月—2024年5月白银市第三人民医院肾病科收治的88例糖尿病肾病患者的临床资料,按照治疗方案不同将患者分为两组,各44例。对照组采用贝那普利治疗,观察组采用恩格列净联合贝那普利治疗。比较两组血糖水平、肾功能、炎症因子水平、不良反应发生情况及治疗有效率。结果治疗后,两组空腹血糖、餐后2 h血糖、糖化血红蛋白、肌酐、胱抑素-C、同型半胱氨酸、尿白蛋白、单核细胞趋化蛋白-1、白细胞介素-6、白细胞介素-8、肿瘤坏死因子-α水平均降低,且观察组低于对照组,差异有统计学意义(P均<0.05)。观察组治疗有效率高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论在贝那普利治疗基础上联合恩格列净治疗糖尿病肾病,不会增加患者不良反应,能够进一步改善患者血糖、肾功能水平,减轻炎症反应,取得更好的治疗效果。

Objective To explore the effect of empagliflozin combined with benazepril in the treatment of patients with diabetic nephropathy.Methods The clinical data of 88 patients with diabetic nephropathy admitted to the Department of Nephrology of Baiyin Third People's Hospital from June 2023 to May 2024 were retrospectively selected.The patients were divided into two groups according to different treatment options,44 cases each.The control group was treated with benazepril,and the observation group was treated with empagliflozin combined with benazepril.The levels of blood glucose,renal function,inflammatory factors,adverse reactions and treatment efficiency were compared between the two groups.Results After treatment,the levels of fasting plasma glucose,2-hour postprandial plasma glucose,glycated hemoglobin A1c,creatinine,cystatin-C,homocysteine,urinary albumin,monocyte chemoattractant protein-1,interleukin-6,interleukin-8 and tumor necrosis factor-αin the two groups decreased,and those in the observation group were lower than the control group,the differences were statistically significant(all P<0.05).The effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion On the basis of benazepril treatment combined with empagliflozin in the treatment of diabetic nephropathy,it will not increase the adverse reactions of patients,can further improve the blood glucose and renal function levels of patients,reduce the inflammatory response,and achieve better therapeutic effect.