胃食管反流病与偏头痛的因果关系:一项孟德尔随机化研究

Causal analysis of the relationship between gastroesophageal reflux disease and migraine:a Mendelian randomization study

目的采用两样本孟德尔随机化方法探究胃食管反流病(gastroesophageal reflux disease,GERD)与偏头痛之间的因果关系。方法研究数据来自GWAS数据库,其中GERD数据包含602604例样本,偏头痛数据包含462933例样本,使用逆方差加权法、MR-Egger和加权中值法三种孟德尔随机化分析方法,采用OR值评估GERD与偏头痛之间的因果关系。同时采用Cochran′s Q检验、MR-Egger截距、留一法(leave-one-out)和漏斗图4种方法进行敏感性分析。结果逆方差加权法结果显示,GERD与偏头痛之间存在正向因果关系(P=0.003),敏感性分析未显示统计多效性。结论孟德尔随机化分析支持GERD与偏头痛的正向因果关系,为偏头痛的预防和治疗提供了参考依据。

Objective To utilize a two-sample Mendelian randomization approach to investigate the causal association between gastroesophageal reflux disease(GERD)and migraine.Methods The study data were obtained from a GWAS database,including 602604 samples for GERD and 462933 samples for migraine.Three Mendelian randomization analysis methods,namely,inverse variance weighting,MR-Egger and weighted median,were used to evaluate the causal relationship between GERD and migraine using odds ratio(OR)as a measure.Sensitivity analyses were conducted using four methods:Cochran's Q test,MR-Egger intercept,leave-one-out and funnel plot.Results The inverse variance weighting method showed that there was a positive causal relationship between GERD and migraine(P=0.003).Sensitivity analysis did not show statistical heterogeneity.Conclusion Mendelian randomization analysis supports a positive causal relationship between GERD and migraine,providing reference basis into the prevention and treatment of migraine.