脑-肠-菌轴在肠易激综合征发病中的研究进展

Research progress on the brain-gut-microbiota axis in the pathogenesis of irritable bowel syndrome

肠易激综合征(irritable bowel syndrome,IBS)是一种普遍存在的消化系统紊乱性疾病,表现为持续的腹部疼痛、排便习惯异常,但通常不伴随器质性改变。近年来,有学者提出脑-肠-微生物组轴(微生物群与自主神经系统之间的神经体液双向集成通信)是引起IBS发生的核心,其中微生物群起着关键作用,可以与中枢神经系统相互影响,因此,“脑-肠-菌轴”一词被引出。本文将围绕脑-肠-菌轴在IBS发病机制中的作用,进一步归纳该轴与IBS的生理病理联系,为研究IBS的发病机制及防治提供理论依据。

Irritable bowel syndrome(IBS)is a common digestive disorder characterized by persistent abdominal pain and abnormal bowel habits,but usually not accompanied by organic changes.In recent years,some scholars have proposed that the brain-gut-microbiota axis(the bidirectional integrated communication between microbiota and the autonomic nervous system)is the core cause of IBS,in which the microbiota plays a crucial role and can interact with the central nervous system,hence the term brain-gut-microbiota axis has been introduced.This article focused on the role of the brain gut microbiota axis in the pathogenesis of IBS,further summarized the physiological and pathological connections between this axis and IBS,and provide theoretical basis for studying the pathogenesis and prevention of IBS.