痛风与心血管疾病的相关性:一项Meta分析

Association Between Gout and Cardiovascular Disease:a Meta-analysis

目的:对痛风(GA)与心血管疾病(CVD)之间的联系进行Meta分析。方法:检索PubMed、Embase、Cochrane Library、Web of Science、Clinicaltrials.gov、中国生物医学文献服务系统、中国知网、维普、万方、中国临床试验注册中心数据库,提取比较GA组与非GA组患者发生心血管疾病的研究,并使用STATA 14.0软件进行统计学分析。结果:纳入21篇文章,Meta分析结果显示,GA会增加CVD的发生风险(RR=1.82,95%CI 1.68~1.97,I^(2)=97.0%,P<0.001)。GA会增加冠状动脉粥样硬化性心脏病(CHD)、心绞痛(AP)、心肌梗死(MI)、心力衰竭(HF)及高血压(HBP)的发生风险(RR=1.75,95%CI 1.48~2.06,I^(2)=90.6%,P<0.001;RR=1.77,95%CI 1.52~2.07,I^(2)=97.8%,P<0.001;RR=2.03,95%CI 1.96~2.11,P<0.001;RR=1.52,95%CI 1.11~2.08,P=0.009;RR=2.93,95%CI 1.69~5.07,I^(2)=98.5%,P<0.001)。结论:GA会增加CVD的发生风险,研究结果对制定新的CVD预防和治疗策略具有积极意义。

Objective:The association between Goutyarthritis and Cardiovascular disease was meta-analyzed.Methods:Search PubMed,Embase,Cochrane Library,Web of Science,Clinical trials.gov,CBM,CNKI,VIP,Wanfang,China Clinical Trial Registry database,Cardiovascular diseases in Goutyarthritis and non-Goutyarthritis control groups were extracted and compared,and statistical analysis was performed using STATA14.0 software.Results:A total of 21 articles were included,Mete analysis showed that the risk of cardiovascular disease in Goutyarthritis was higher than that in control group(RR=1.82,95%CI:1.68~1.97,I^(2)=97.0%,P<0.001).Goutyarthritis increased the risk of CHD,AP,MI,HFand HBP,and the relative risk was(RR=1.75,95%CI:1.48~2.06,I^(2)=90.6%,P<0.001;RR=1.77,95%CI:1.52~2.07,I^(2)=97.8%,P<0.001;RR=2.03,95%CI:1.96~2.11,P<0.001;RR=1.52,95%CI:1.11~2.08,P<0.001;RR=2.93,95%CI:1.69~5.07,I^(2)=98.5%,P<0.001).Conclusion:GA increases the risk of CVD,and the findings have positive implications for developing new strategies for the prevention and treatment of CVD.