胞磷胆碱注射液联合吡拉西坦对颅脑损伤患者的影响

Effect of Citicoline Injection Combined with Piracetam on Patients with Traumatic Craniocerebral Injury

目的:探究胞磷胆碱注射液联合吡拉西坦对颅脑损伤患者的影响。方法:选取2022年6月—2023年6月福建省汀州医院神经外科收治的82例颅脑损伤患者开展前瞻性研究。根据随机数表法将其分为两组,各41例。对照组给予吡拉西坦治疗,观察组在对照组基础上给予胞磷胆碱注射液。比较两组治疗前后氧化应激指标、神经元损伤程度、神经损伤修复指标、神经功能、认知功能及不良反应。结果:治疗后,两组丙二醛(MDA)、过氧化脂质(LPO)均降低,总抗氧化能力(TAOC)、超氧化物歧化酶(SOD)均升高,观察组MDA、LPO均低于对照组,TAOC、SOD均高于对照组,差异有统计学意义(P<0.05)。治疗后,两组胶质纤维酸性蛋白(GFAP)、髓鞘碱性蛋白(MBP)、神经元特异性烯醇化酶(NSE)均降低,观察组GFAP、MBP、NSE均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组热休克蛋白-90(HSP-90)、神经生长因子(NGF)均降低,观察组HSP-90、NGF均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组美国国立卫生研究院卒中量表(NIHSS)评分降低,简易智能状态量表(MMSE)评分升高,观察组NIHSS评分低于对照组,MMSE评分高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:胞磷胆碱注射液联合吡拉西坦可减轻颅脑损伤患者氧化应激反应,减轻神经元损伤,保护神经功能,提高认知功能,且无严重不良反应。

Objective:To investigate the effect of Citicoline Injection combined with Piracetam on patients with traumatic craniocerebral injury.Method:A prospective study of 82 patients with craniocerebral injury admitted to the Department of Neurosurgery in Tingzhou Hospital in Fujian Province from June 2022 to June 2023 was conducted.They were divided into two groups by random number table method,41 cases in each group.The control group was given Piracetam,and the observation group was given Citicoline Injection on the basis of the control group.The oxidative stress index,neuronal damage degree,nerve damage repair index,nerve function,cognitive function before and after treatment and adverse reactions were compared between the two groups.Result:After treatment,malondialdehyde(MDA)and lipid peroxide(LPO)were decreased,and total antioxidant capacity(TAOC)and superoxide dismutase(SOD)were increased in both groups,MDA and LPO in observation group were lower than those in control group,and TAOC and SOD were higher than those in control group,the differences were statistically significant(P<0.05).After treatment,glial fibrillary acidic protein(GFAP),myelin basic protein(MBP)and neuronal specific enolase(NSE)in both groups were decreased,and GFAP,MBP and NSE in observation group were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,heat shock protein-90(HSP-90)and nerve growth factor(NGF)were decreased in both groups,and HSP-90 and NGF in observation group were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,National Institutes of Health stroke scale(NIHSS)score decreased and mini mental state examination(MMSE)score increased in both groups,the NIHSS score in the observation group was lower than that in the control group,and the MMSE score was higher than that in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Citicoline Injection combined with Piracetam can alleviate oxidative stress reaction,reduce neuronal injury,protect nerve function and improve cognitive function in patients with craniocerebral injury,and has certain application value without serious adverse reactions.