硝苯地平和硫酸镁注射液联合用于妊娠期高血压疾病孕妇治疗的有效性及安全性

Effectiveness and Safety of Nifedipine Combined with Magnesium Sulfate Injection in the Treatment of Pregnant Women with Hypertensive Disorders of Pregnancy

目的:探讨硝苯地平和硫酸镁注射液用于妊娠期高血压疾病(HDP)孕妇治疗的有效性及安全性。方法:选择2022年5月—2023年5月于福建省漳州市医院产科就诊的86例HDP孕妇,按随机数表法分为对照组和观察组,各43例。对照组给予硫酸镁注射液治疗,观察组给予硝苯地平联合硫酸镁注射液治疗。比较两组临床疗效、症状改善时间、血压复常时间、血压水平[收缩压(SBP)、舒张压(DBP)]、不良妊娠结局及不良反应。结果:观察组治疗总有效率(95.35%)高于对照组(81.40%),水肿、头晕恶心、视物模糊、蛋白尿改善时间及血压复常时间均短于对照组;治疗后,两组SBP、DBP水平低于治疗前,且观察组低于对照组;观察组不良妊娠结局发生率及不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:在硫酸镁注射液治疗HDP孕妇基础上,加用硝苯地平可取得更显著的疗效,不仅可有效改善血压水平,加速症状缓解,且可降低不良妊娠结局及不良反应发生率。

Objective:To explore the effectiveness and safety of Nifedipine combined with Magnesium Sulfate Injection in the treatment of pregnant women with hypertensive disorders of pregnancy(HDP).Method:A total of 86 pregnant women with HDP who treated in the Obstetrics Department of Zhangzhou Municipal Hospital of Fujian Province from May 2022 to May 2023 were selected as the study objects,and they were divided into the control group and the observation group according to the random number table method,with 43 cases in each group.The control group was treated with Magnesium Sulfate Injection,while the observation group was treated with Nifedipine combined with Magnesium Sulfate Injection.The clinical efficacy,symptom improvement time,blood pressure normalization time,blood pressure levels[systolic blood pressure(SBP),diastolic blood pressure(DBP)],adverse pregnancy outcomes and adverse reactions between two groups were compared.Result:The total effective rate of the observation group was 95.35%,which was higher than 81.40%of the control group;the improvement times of edema,dizziness,nausea,blurred vision,proteinuria and blood pressure normalization time in the observation group were shorter than those in the control group;after treatment,the levels of SBP and DBP in two groups were lower than those before treatment,and those in the observation group were lower than those in the control group;the incidence of adverse pregnancy outcomes and adverse reactions in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion:On the basis of Magnesium Sulfate Injection in the treatment of pregnant women with HDP,Nifedipine can achieve more significant curative effect,which can not only effectively improve blood pressure level,accelerate symptom relief,but also reduce the incidence of adverse pregnancy outcomes and adverse reactions.