心脏超声评价葶苈大枣泻肺汤抗阳虚血瘀型心力衰竭的研究

Evaluation of Tingli Dazao Xiefei Decoction(葶苈大枣泻肺汤)on Yang Deficiency and Blood Stasis Type of Heart Failure by Cardiac Ultrasound

目的分析心脏超声评价葶苈大枣泻肺汤抗阳虚血瘀型心力衰竭的研究。方法纳入2022年8月—2023年9月山东中医药大学附属医院心血管病科收治的阳虚血瘀型心力衰竭患者94例为研究对象,随机数字表法将其分为两组,对照组47例采用常规治疗,观察组47例在此基础上采用葶苈大枣泻肺汤治疗,对比两组疗效差异,并用心脏超声评价治疗前后心功能指标变化情况等。结果观察组治疗总有效率为95.74%(45/47),远高于对照组的76.60%(36/47),组间比较差异有统计学意义(P<0.05);治疗后观察组心脏指数(cardiac index,CI)、每搏量(strokevolume,SV)、心脏每分钟搏出量(cardiac output,CO)、射血分数(ejection fraction,EF)高于对照组,组间比较差异有统计学意义(P<0.05);治疗后观察组左心室舒张末期容积(left ventricular end diastolic volume,LVEDV)、左心室收缩末期容积(left ventricular end-systolic volume,LVESV)、左心室舒张末期内径(left ventricular end diastolic dimension,LVDd)、左心室收缩末期内径(left ventricularend-systolic dimension,LVDs)低于对照组,组间比较差异有统计学意义(P<0.05)。结论葶苈大枣泻肺汤治疗阳虚血瘀型心力衰竭患者效果明确,能有效抑制心室重构,促进心功能恢复,促进患者病情改善;在治疗期间用心脏超声观察有利于准确评价患者心脏功能及心脏形态变化情况,为临床诊治提供必要参考依据,有较高应用价值。

Objective To analyze the effect of Tingli Dazao Xiefei Decoction(葶苈大枣泻肺汤)on Yang deficiency and blood stasis type of heart failure by cardiac ultrasonography.Methods Ninety-four patients with Yang deficiency and blood stasis type of heart failure treated in Department of Cardiovascular Disease,Affiliated Hospital of Shandong University of Traditional Chinese Medicine from August 2022-September 2023 were included as the study objects.They were divided into two groups by random number table method.Forty-seven patients in the control group received conventional treatment,and the other 47 patients in the observation group were treated with Tingli Dazao Xiefei Decoction on the basis of this treatment.The difference of curative effect between the two groups was compared,and the changes of cardiac function indexes before and after treatment were evaluated by cardiac ultrasound.Results The total effective rate of the observation group was 95.74%,which was much higher than that of the control group(76.60%),and the difference was significant(P<0.05).After treatment,the values of cardiac index(CI),stroke volume(SV),stroke volume per minute(CO)and ejection fraction(EF)in the observation group were higher than those in the control group,and the differences were significant(P<0.05).After treatment,the values of left ventricular end-diastolic volume(LVEDV),left ventricular end-systolic volume(LVESV),left ventricular end-diastolic diameter(LVDd)and left ventricular end-systolic diameter(LVDs)in the observation group were lower than those in the control group,and the differences were significant(P<0.05).Conclusion Tingli Dazao Xiefei Decoction has clear effect in the treatment of Yang deficiency and blood stasis type of heart failure,and can effectively inhibit ventricular remodeling,promote the recovery of heart function and promote the improvement of patients'condition.Cardiac ultrasound observation during treatment is beneficial to accurately evaluate the cardiac function and cardiac morphological changes of patients,providing necessary reference for clinical diagnosis and treatment,and has high application value.