联用还原型谷胱甘肽、苯巴比妥治疗新生儿黄疸的临床效果

Clinical Study on Reduced Glutathione Combined with Phenobarbital in Treatment of Neonatal Jaundice

目的探索联用还原型谷胱甘肽、苯巴比妥药物治疗新生儿黄疸的效果。方法选择2022年1月—2023年12月本院收治的新生儿黄疸病例80例,采用随机数字法将其分为观察组和对照组,每组40例,分析不同治疗方式的效果。结果治疗后,两组肝功能各项指标均降低,观察组肝功能较对照组更低(P<0.05);治疗后,观察组首次排便时间、胎便排空时间、黄疸消退时间、住院时间均较对照组更短,大便次数较对照组多(P<0.05);治疗后,两组总胆红素、直接胆红素、间接胆红素水平均降低,观察组较对照组更低(P<0.05)。结论运用还原型谷胱甘肽+苯巴比妥疗法治疗新生儿黄疸,可促使新生儿胆红素水平、肝功能改善,加快患儿康复,建议运用。

Objective To explore effect of reduced glutathione combined with phenobarbital drugs for neonatal jaundice.Methods The paper chose 80 cases of neonatal jaundice in our hospital from January 2022 to December 2023,and divided them into observation group and control group randomly,with 40 cases in each group.Curative effect of different treatment methods was analyzed.Results After treatment,liver function of observation group was better,P<0.05;symptom improvement time of observation group was lower,P<0.05.After treatment,bilirubin level of observation group was better,P<0.05.Conclusion Reduced glutathione+phenobarbital therapy can improve neonatal bilirubin level and liver function,accelerate recovery of neonatal jaundice,which can be recommended for application.