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骨性关节炎患者血清及关节液中骨桥蛋白、IL-17的表达水平及其影响因素分析

Analysis of expression levels of osteopontin and IL-17 in serum and synovial fluid of patients with osteoarthritis and their influencing factors
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摘要 目的分析骨性关节炎(OA)患者血清及关节液中骨桥蛋白(OPN)、白细胞介素-17(IL-17)的表达水平及其影响因素。方法选择行关节镜手术的患者作为研究对象,其中骨性关节炎(骨性关节炎组)及关节疾病(非骨性关节炎组)患者各40例,以非骨性关节炎组作为对照。比较两组临床资料,包括一般资料[年龄、性别、体质量指数(BMI)、病程]、血清及关节液中OPN、IL-17水平、Outerbridge软骨损伤累计评分、Ayral滑膜炎评分;分析骨性关节炎发病的影响因素。结果两组年龄、性别、BMI、病程比较无明显差异(P>0.05)。骨性关节炎组血清IL-17(366.24±90.17)pg/ml、血清OPN(4.92±0.87)ng/ml、关节液IL-17(377.46±87.24)pg/ml、Outerbridge软骨损伤累计评分(20.03±3.11)分、Ayral滑膜炎评分(60.46±20.12)分明显高于非骨性关节炎组的(237.24±60.04)pg/ml、(0.97±0.35)ng/ml、(256.46±65.33)pg/ml、(10.03±0.03)分、(22.13±10.35)分,差异显著,有统计学意义(P<0.05)。Logistic回归分析显示,血清IL-17、血清OPN、关节液IL-17、Outerbridge软骨损伤累计评分、Ayral滑膜炎评分均是骨性关节炎发病的独立危险因素(OR=15.863、23.665、20.369、17.219、70.176,P<0.05)。结论血清IL-17、血清OPN、关节液IL-17、Outerbridge软骨损伤累计评分、Ayral滑膜炎评分均是骨性关节炎发病的独立危险因素,能够作为评估骨性关节炎的有效指标,为骨性关节炎的诊断和治疗提供一定的临床依据及参考。 Objective To analyze the expression levels of osteopontin(OPN)and interleukin-17(IL-17)in serum and synovial fluid of patients with osteoarthritis(OA)and their influencing factors.Methods Patients who underwent arthroscopic surgery were selected as the study subjects,including 40 cases of osteoarthritis(osteoarthritis group)and 40 cases of joint disease(non-osteoarthritis group),with the non-osteoarthritis group as the control.The clinical data,including general data[age,gender,body mass index(BMI),disease duration],levels of OPN and IL-17 in serum and synovial fluid,score of Outerbridge cartilage injury and the score of Ayral synovitis,of the two groups was compared.The influencing factors of osteoarthritis were analyzed.Results There were no significant differences in age,gender,BMI and course of disease between the two groups(P>0.05).In osteoarthritis group,the serum IL-17 was(366.24±90.17)pg/ml,the serum OPN was(4.92±0.87)ng/ml,IL-17 in synovial fluid was(377.46±87.24)pg/ml,the score of Outerbridge cartilage injury was(20.03±3.11)points,and the score of Ayral synovitis was(60.46±20.12)points,which were significantly higher than(237.24±60.04)pg/ml,(0.97±0.35)ng/ml,(256.46±65.33)pg/ml,(10.03±0.03)points,and(22.13±10.35)points in non-osteoarthritis group.The difference was statistically significant(P<0.05).Logistic regression analysis showed that serum IL-17,serum OPN,IL-17 in synovial fluid,score of Outerbridge cartilage injury and score of Ayral synovitis were all independent risk factors for the onset of osteoarthritis(OR=15.863,23.665,20.369,17.219,70.176;P<0.05).Conclusion Serum IL-17,serum OPN,IL-17 in synovial fluid,score of Outerbridge Cartilage injury,and score of Ayral Synovitis are independent risk factors for the development of osteoarthritis,and they can be used as effective indicators for the assessment of osteoarthritis,which can provide certain clinical bases and references for the diagnosis and treatment of osteoarthritis.
作者 张源林 许段女 黄小华 刘习娟 刘德胜 ZHANG Yuan-lin;XU Duan-nyu;HUANG Xiao-hua(People's Hospital of Yudu County,Ganzhou 342300,China)
出处 《中国实用医药》 2024年第20期68-71,共4页 China Practical Medicine
基金 2022年度赣州市社会发展指导性科技计划项目一般课题(项目编号:20222ZDX9045)项目名称:骨性关节炎患者血清及关节液中骨桥蛋白、IL-17的表达水平与病情相关性研究。
关键词 骨性关节炎 白细胞介素-17 骨桥蛋白 Outerbridge软骨损伤累计评分 Ayral滑膜炎评分 Osteoarthritis Interleukin-17 Osteopontin Score of Outerbridge cartilage injury Score of Ayral synovitis
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