子宫内膜息肉与胰岛素抵抗的关系研究进展

Research progress on correlation of endometrial polyp with insulin resistance

子宫内膜息肉(EP)是育龄女性中常见的良性疾病,可导致异常子宫出血及不孕,但患者多无明显症状,仅在超声或宫腔镜检查中发现。目前其发病原因尚未明确,研究提示肥胖、糖尿病、高脂血症等代谢异常患者是高危人群,可见胰岛素抵抗(IR)在其发生发展中占有重要地位,可能与胰岛素受体表达及下游信号通路异常有关,本文就EP与IR的关系进行综述。

Endometrial polyp(EP)is a common benign disease among women of reproductive age,which can lead to abnormal uterine bleeding and infertility.However,most patients have no obvious symptoms and are diagnosed only during the examination of ultrasound or hysteroscopy.At present,the etiology of EP has not been identified.Research suggests that the high-risk population includes patients with metabolic abnormalities such as obesity,diabetes,hyperlipidemia.Accordingly,insulin resistance(IR)seems to play an important role in the occurrence and development of EP,which may be related to the abnormal expression of insulin receptor and downstream signal pathways.This article reviews the relationship between EP and IR.