铁死亡的病理生理学机制研究进展

Advances in the pathophysiological mechanisms of ferroptosis

铁死亡作为一种新型的细胞死亡形式,近年来受到病理生理学领域的广泛关注。本文综述了铁死亡的病理生理学机制及其在多种疾病中的潜在作用,进一步提出铁死亡的关键分子和信号通路的相互作用、疾病中的异质性表现、治疗策略的评估与优化、与其他细胞死亡方式的关系,以及治疗策略的个体化和精准化等一系列问题,为铁死亡研究提供方向,并促进相关疾病的治疗策略发展。

Ferroptosis,a new form of regulated cell death,has gained significant attention in the field of patho-physiology in recent years.This review summarizes the pathophysiological mechanisms of ferroptosis and its potential roles in various diseases.Furthermore,we propose a series of questions,including the interaction of key molecules and signaling pathways in ferroptosis,heterogeneity in diseases,assessment and optimization of therapeutic strategies,relationships with other forms of cell death,and individualization and precision of therapeutic strategies.This review aims to provide direction for future research on ferroptosis and to promote the development of therapeutic strategies for related diseases.