电子支气管镜下冷冻及注药治疗肺结核并发支气管结核的效果

The Effect of Cryotherapy and Drug Injection under Electronic Bronchoscopy in the Treatment of Pulmonary Tuberculosis Complicated with Bronchial Tuberculosis

目的评估电子支气管镜下冷冻及注药应用在肺结核(PTB)并发支气管结核(BT)患者中的效果。方法纳入2021年5月—2023年8月扬州市第三人民医院收治的80例PTB并发BT患者,依据随机数表法分为对照组(纳入40例,给予常规抗结核治疗)、观察组(纳入40例,加用电子支气管镜下冷冻及注药治疗),比较两组临床有效率、免疫功能、炎症因子、康复相关时间。结果观察组临床有效率高于对照组,各项康复相关时间短于对照组,差异有统计学意义(P<0.05)。治疗前,两组免疫功能(CD8^(+)、CD4^(+)、CD3^(+))、炎症因子[降钙素原(PCT)、C反应蛋白(CRP)、白细胞介素-6(IL-6)]比较,差异无统计学意义(P>0.05);治疗4周后,观察组CD8^(+)、PCT、CRP、IL-6低于对照组,CD4^(+)、CD3^(+)高于对照组,差异有统计学意义(P<0.05)。结论对PTB并发BT患者实施电子支气管镜下冷冻及注药治疗,可以提高临床有效率,增强免疫功能,缓解炎症反应,缩短病程,有临床借鉴意义。

Objective To evaluate the effect of electronic bronchoscopic freezing and drug injection in patients with pulmonary tuberculosis(PTB)complicated by bronchial tuberculosis(BT).Methods A total of 80 patients with PTB complicated with BT from May 2021 to August 2023 were included and grouped according to random number table method,namely:The control group(40 cases included and given conventional anti-tuberculosis treatment)and the observation group(40 cases included and given freezing and drug injection under electronic bronchoscopy)were evaluated for clinical response rate,immune function,inflammatory factors and time related to recovery.Results Compared with the control group,the clinical effective rate of the observation group was higher and the time related to rehabilitation was shorter,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in immune function(CD8^(+),CD4^(+),CD3^(+))and inflammatory factors[procalcitonin(PCT),C-reactive protein(CRP),interleukin-6(IL-6)]between groups(P>0.05).After 4 weeks of treatment,CD8^(+),PCT,CRP and IL-6 were lower in the observation group,and CD4^(+)and CD3^(+)were higher,with statistical significance(P<0.05).Conclusion Freezing and drug injection under electronic bronchoscope for patients with PTB complicated with BT can improve clinical efficiency,enhance immune function,relieve inflammation,shorten the course of disease,and have clinical reference significance.