化浊行血汤治疗痰瘀阻络型脑梗死恢复期的临床研究

Clinical Study on the Treatment of Phlegm Stasis Blocking Collateral Type Cerebral Infarction in the Recovery Period with Huazhuo Xingxue Decoction

目的探讨与分析化浊行血汤治疗痰瘀阻络型脑梗死恢复期的临床效果。方法选择2020年8月—2023年2月天津市河东区中医医院收治的98例痰瘀阻络型脑梗死恢复期患者作为研究对象,根据1:1随机数表法把98例患者分为中医组49例与对照组49例。对照组给予常规西医治疗,中医组在对照组治疗的基础上给予化浊行血汤治疗。两组均治疗观察2个月,比较两组治疗前后神经功能缺损评分、精神状态与认知功能评分、大脑中动脉血流速度变化、生活质量评分。结果治疗2个月后两组患者神经功能缺损评分均较治疗前下调,与对照组比较,中医组下调的程度更大,差异具有统计学意义(P<0.05);治疗2个月后两组患者精神状态与认知功能评分较治疗前升高,与对照组比较,中医组升高的程度更大,差异具有统计学意义(P<0.05);两组患者治疗的脑中动脉舒张期末血流速度和收缩期峰血流速度较治疗前升高,与对照组比较,中医组升高的程度更大,差异具有统计学意义(P<0.05);治疗2个月后中医组的生活质量得分与对照组比较有较大程度的升高,差异具有统计学意义(P<0.05)。结论化浊行血汤治疗痰瘀阻络型脑梗死恢复期能改善患者的神经缺损状况,提高患者的精神状态与认知功能评分,改善患者的大脑中动脉血流速度,从而提高患者的生活质量。

Objective To explore and analysis the clinical effect of Huazhuo Xingxue Tang on the recovery stage of cerebral infarction of phlegm stasis obstruction type.Methods A total of 98 patients with phlegm stasis obstruction type cerebral infarction during the recovery period diagnosed and treated at Hedong District Traditional Chinese Medicine Hospital in Tianjin from August 2020 to February 2023 were selected as the research subjects.Accorded to a 1:1 random number table method,the 98 patients were divided into the traditional Chinese medicine group of 49 cases and the control group of 49 cases.The control group were treated with conventional Western medicine,while the traditional Chinese medicine group were treated with Huazhuo Xingxue Tang on the basis of the control group.Both groups were treated and observed for 2 months,and the scores of nerve function deficit,mental state and cognitive function,changes in middle cerebral artery bloodflow velocity and quality of life were compared between the two groups before and after treatment.Results After 2 months of treatment,the neurological deficit scores of both groups of patients decreased compared to before treatment,and the degree of downregulation in the traditional Chinese medicine group was greater.Compared with the control group,the difference was statistically significant(P<0.05);After 2 months of treatment,the mental state and cognitive function scores of the two groups of patients increased compared to before treatment,and the degree of increase was greater in the traditional Chinese medicine group.Compared with the control group,the difference was statistically significant(P<0.05);The end diastolic bloodflow velocity and peak systolic bloodflow velocity of the middle cerebral artery in the two groups of patients treated increased compared to before treatment,and the degree of increase in the traditional Chinese medicine group was greater.Compared with the control group,the difference was statistically significant(P<0.05);The quality of life scores of the traditional Chinese medicine group after two months of treatment showed a significant increase compared to the control group,and the difference was statistically significant(P<0.05).Conclusion Huazhuo Xingxue Tang can improve patients'neurological deficits,improve their mental state and cognitive function scores,improve the blood flow velocity of the middle cerebral artery,and thus improve their quality of life in the recovery period of phlegm stasis obstruction type cerebral infarction.