Lisa管注入珂立苏联合咖啡因对呼吸窘迫综合征近远期疗效的观察

Short and Long Term Effect Observation of Lisa Tube Injection of Calsurf Combined with Caffeine in Treatment of Respiratory Distress Syndrome

目的 探究在呼吸窘迫综合征患者中将Lisa管注入珂立苏与咖啡因法进行联合应用对患者的影响效果。方法 选取2022年9月—2023年9月本院收治的100例呼吸窘迫综合征患者为研究对象,根据随机法将患者分为实验组和对照组,每组50例。其中,实验组给予Lisa管注入珂立苏与咖啡因法联合治疗,对照组给予单纯的咖啡因治疗,对比分析不同方法对新生儿治疗效果、气血指标和并发症发生率的影响效果。结果 实验组总有效率显著高于对照组(P<0.05)。治疗前,两组新生儿的各项气血指标对比,差异无统计学意义(P>0.05);治疗后,各项指标均发生变化,其中实验组的PaCO_(2)更低,PaO_(2)、PaO_(2)/FiO_(2)和pH值均更高(P<0.05)。同时,实验组新生儿并发症发生率低于对照组(P<0.05)。结论 在呼吸窘迫综合征的治疗中,将咖啡因与通过Lisa管注入珂立苏的方法联合应用的效果显著,对改善患者的气血状态、提升临床治疗成功率以及减少不良反应的发生均起到了积极作用,具有重要的临床意义。

Objective To investigate effect of Lisa tube injection combined with caffeine method for patients with respiratory distress syndrome.Methods The paper chose 100 patients with respiratory distress syndrome in our hospital from September 2022 to September 2023 for research experiment,and randomly divided them into two groups according to the requirements of the comparative experiment,50 cases in each group,namely experimental group and control group.The former was treated with Lisa tube injection combined with calsurf and caffeine therapy,while the latter with simple caffeine therapy.Effect of different methods for qi and blood indicators and complications incidence of newborns was compared and analyzed.Results There was significant difference in curative effect between two groups of newborns(P<0.05),with statistical significance.There were 46 effective cases in experimental group,with an effective rate of 92.00%,significantly higher than 34 effective cases in control group,with an effective rate of 68.00%.Before treatment,there was no significant difference in various qi and blood indicators between two groups,which were relatively similar(P>0.05).After treatment,all indicators changed,PaCO_(2)(5.33±2.12)in experimental group was lower,and PaO_(2)(13.23±3.23),PaO_(2)/FiO_(2)(149.56±18.34),pH value(7.45±0.08)was higher than control group,data showed significant difference,P<0.05.Meanwhile,both groups of newborns had complications during treatment,there was significant difference in incidence rate,P<0.05.Incidence rate of newborns in experimental group was 6.00%,lower than 28.00%in control group.Conclusion Patients with respiratory distress syndrome are in critical condition and require active treatment.Caffeine combined with Lisa tube injection with calsurf can achieve significant effect,improve Qi and blood indicators,clinical treatment efficiency,and reduce incidence of adverse reactions of patients,which has remarkable significance.