高血压危象患者中医证型分布规律与视网膜病变程度、miR-92a水平相关性研究

Correlation Study between Distribution Pattern of TCM Syndrome Types and Retinal Lesions Degree and Mir-92a Levels of Patients with Hypertensive Crisis

目的 通过分析高血压危象患者中医证型分布规律、视网膜病变程度及miR-92a水平相关度研究,明确高血压与微循环受损关系,用以未病先防。方法 选取2022年1—12月本院心内科收治的73例高血压危象患者作为研究对象,依据证型的不同,将其分为实证组(45例),其中包括肝阳上亢证组(20例)、气滞血瘀证组(13例)、痰湿壅盛证组(12例),以及虚实夹杂证组,即阴虚阳亢证组(18例),虚证组,即肝肾阴虚证组(10例),入院次日清晨空腹测定相关检测指标,并行FFA检查。结果 高血压急症各证型组中实证患者ADT、VFT、CET、miR-92a高于虚实夹杂证及虚证患者,MD低于虚实夹杂证及虚证患者(P<0.05);采用多元回归分析,实证组与miR-92a 的表达量、视网膜病变呈正相关,差异有统计学意义(P<0.05)。结论 中医实证分布、视网膜病变程度、循环miR-92a水平在高血压危象中明显升高,有可能作为早期诊断高血压急症的客观指标,并为临床预防高血压急症发生提供未病先防依据。

Objective To analyze distribution pattern of TCM syndrome types,retinal lesions degree and correlation between miR-92a levels of patients with hypertensive crisis,clarify relationship between hypertension and microcirculation damage,and prevent the disease before it occurs.Methods The paper chose 73 patients with hypertensive crisis in cardiology department of our hospital from January 2022 to December 2022,and divided them into empirical groups(45 cases)according to different syndrome types,including liver Yang hyperactivity syndrome group(20 cases),qi stagnation and blood stasis syndrome group(13 cases),phlegm dampness stagnation syndrome group(12 cases),and combination of deficiency and excess syndrome group,ie Yin deficiency and Yang hyperactivity syndrome group(18 cases),and deficiency syndrome group,ie liver kidney Yin group(10 cases).Relevant fasting indicators were measured the next morning after admission,FFA examination was performed.Results ADT,VFT,CET and miR-92a of patients with hypertension were higher than those with deficiency combined excess syndrome and deficiency syndrome,and MD was lower than those with deficiency combined excess syndrome and deficiency syndrome(P<0.05).Multiple regression analysis showed,expression level of miR-92a in empirical group was positively correlated with retinal lesions,difference was statistically significant(P<0.05).Conclusion Distribution of traditional Chinese medicine evidence,degree of retinal lesions,and circulating miR-92a levels are significantly elevated for hypertensive crisis,which may be objective indicators for early diagnosis of hypertensive crisis and provide basis for its prevention before occur in clinical practice.