辅酶Q10对乳腺癌患者化疗期间主要不良心血管事件的影响

Effect of coenzyme Q Effect of coenzyme Q10 on major adverse cardiovascular event during chemotherapy in breast cancer patients

目的探讨辅酶Q10(CoQ10)对乳腺癌患者化疗期间主要不良心血管事件(MACE)的影响。方法根据化疗期间是否使用CoQ10将122例乳腺癌患者分为对照组(n=68,未使用CoQ10)和观察组(n=54,使用CoQ10),比较两组患者MACE发生情况。根据MACE发生情况将所有患者分为MACE组和非MACE组,比较两组患者的临床特征,采用Logistic回归模型分析乳腺癌患者化疗期间发生MACE的影响因素。结果观察组患者MACE发生率为22.22%,低于对照组患者的44.12%,差异有统计学意义(P<0.05)。122例患者中,发生MACE 42例,MACE发生率为34.43%。MACE组患者中年龄≥50岁、合并高血压、合并高血脂、化疗期间未使用CoQ10的比例均高于非MACE组,差异均有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,合并高血压、合并高血脂、化疗期间未使用CoQ10均是乳腺癌患者化疗期间发生MACE的危险因素(P<0.01)。结论乳腺癌患者化疗期间MACE发生率较高,CoQ10能够降低MACE发生率,MACE的发生与高血压、高血脂密切相关,应给予密切关注。

Objective To explore the effect of coenzyme Q10(CoQ10)on major adverse cardiovascular event(MACE)during chemotherapy in breast cancer patients.Method According to whether or not CoQ10 was used during chemotherapy,122 breast cancer patients were divided into control group(n=68,CoQ10 was not used)and observation group(n=54,CoQ10 was used),and the occurrence of MACE between the two groups was compared.According to the occurrence of MACE,all patients were divided into MACE group and non-MACE group,the clinical features of the two groups were compared,and the influencing factors of MACE in breast cancer patients during chemotherapy were analyzed by Logistic regression model.Result The incidence of MACE in observation group was 22.22%,lower than 44.12%in control group,and the difference was statistically significant(P<0.05).Among 122 patients,MACE occurred in 42 patients,and the incidence rate of MACE was 34.43%.The proportions of patients with age≥50 years old,hypertension,hyperlipidemia and non-use of CoQ10 during chemotherapy in MACE group were higher than those in non-MACE group,and the differences were statistically significant(P<0.05).Multivariate Logistic regression analysis showed that hypertension,hyperlipidemia and non-use of CoQ10 during chemotherapy were risk factors for MACE in breast cancer patients during chemotherapy(P<0.01).Conclusion The incidence of MACE is high in breast cancer patients during chemotherapy,and CoQ10 can reduce the incidence of MACE.The occurrence of MACE is closely related to hypertension and hyperlipidemia,which should be paid close attention to.