小蓟饮子治疗血精症患者的临床观察

Clinical Efficacy of Xiaoji Decoction in Treatment of Patients with Hematospermia

目的探讨小蓟饮子治疗血精症患者的临床疗效。方法选取2022年9月—2023年6月期间暨南大学附属顺德医院收治的血精症患者64例,按照随机数字表分为对照组和治疗组,每组各32例。对照组给予常规治疗,治疗组在常规治疗的基础上给予小蓟饮子治疗。治疗4周后,观察比较两组患者临床疗效及不良反应情况,治疗前后中医证候积分、疼痛程度及勃起功能、精液血清B(Inhibin B,INH B)、红细胞(Red blood cell,RBC)、白细胞(White blood cell,WBC)、精液分析。结果治疗后治疗组总有效率96.88%(31/32)明显高于对照组78.13%(25/32),差异有统计学意义(P<0.05)。治疗后两组患者精液呈鲜红色、口燥唇焦、身热面赤、腹满痛拒按、阳痿、早泄评分均较治疗前降低,差异有统计学意义(P<0.05);且治疗组精液呈鲜红色、口燥唇焦、身热面赤、腹满痛拒按、阳痿、早泄评分均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者疼痛程度评分较治疗前降低,勃起功能评分较治疗前升高,差异有统计学意义(P<0.05);且治疗组疼痛程度评分明显低于对照组,勃起功能评分明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者精液中RBC、WBC水平均较治疗前降低,精液中INH B水平均较治疗前升高,差异有统计学意义(P<0.05);且治疗组精液中RBC、WBC水平均明显低于对照组,精液中INH B水平明显高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者精子数量、精子形态及活力(前向运动精子、精子总活力)水平均优于治疗前,差异有统计学意义(P<0.05);且治疗组精液数量、精子形态及活力(前向运动精子、精子总活力)水平均明显优于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论小蓟饮子能够有效改善血精症患者临床症状,疗效明显。

Objective To explore the clinical efficacy of Xiaoji Decoction in treating patients with hematospermia.Methods A total of 64 patients diagnosed with hematospermia at the Affiliated Shunde Hospital of Jinan University from September 2022 to June 2023 were selected and randomly divided into a control group and a treatment group according to a random number table,with 32 patients in each group.The control group received conventional treatment,while the treatment group received Xiaoji Decoction in addition to conventional treatment.After four weeks of treatment,clinical efficacy and adverse reactions were compared between the two groups,alongside traditional Chinese medicine(TCM)syndrome scores,pain levels,erectile function,and semen analysis,including serum inhibin B(INH B),red blood cells(RBC),and white blood cells(WBC)before and after treatment.Results The total effective rate in the treatment group was 96.88%(31/32),significantly higher than 78.13%(25/32)in the control group(P<0.05).After treatment,scores for symptoms such as fresh red semen,dry mouth,feverish body,red face,abdominal fullness with pain,impotence,and premature ejaculation decreased significantly in both groups compared to pre-treatment scores(P<0.05),with the treatment group showing significantly lower scores than the control group(P<0.05).Pain scores decreased and erectile function scores increased in both groups after treatment(P<0.05);the treatment group had significantly lower pain scores and higher erectile function scores than the control group(P<0.05).Both groups showed a reduction in RBC and WBC levels in semen and an increase in INH B levels after treatment(P<0.05);the treatment group had significantly lower RBC and WBC levels and higher INH B levels than the control group(P<0.05).Sperm count,morphology,and motility(forward motility and total motility)improved in both groups compared to those before treatment(P<0.05),with the treatment group showing significantly better results than the control group(P<0.05).There were no significant differences in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Xiaoji Decoction effectively improves clinical symptoms in patients with hematospermia,demonstrating significant efficacy.