线粒体自噬调节骨重建及药物干预作用的研究进展

Advances in mitochondrial autophagy regulation of bone remodeling and the role of drug intervention

骨重建是一个复杂的过程,包括骨吸收和骨形成两个相互协调的阶段,对于预防骨骼老化,增加骨密度有重要作用。近年来,研究表明线粒体自噬(mitophagy)在骨吸收和骨形成的过程中起到重要调控作用。线粒体自噬是一种特殊的细胞清理过程,通过清除受损的线粒体来维持线粒体的正常功能和代谢。随着对线粒体自噬调控机制的深入了解,结合药物干预的研究,有望开发出更有效的治疗方法,以改善骨质疏松等骨科相关疾病患者的生活质量。同时,这也将为骨科相关疾病的预防和治疗提供新的视角和策略。

Bone remodeling is a complex process that includes two mutually coordinated phases of bone tion and bone formation,which plays an important role in preventing bone aging and increasing bone density.In recent years,studies have shown that mitochondrial autophagy(mitophagy)plays an important regulatory role in the process of bone resorption and bone formation.Mitochondrial autophagy is a special cellular clearance process that maintains normal mitochondrial function and metabolism by removing damaged mitochondria.With the in-depth understanding of the regulatory mechanisms of mitophagy,combined with the study of drug interventions,it is expected that more effective treatments will be developed to improve the quality of life of patients with orthopedic-related diseases such as osteoporosis.At the same time,it will also provide new perspectives and strategies for the prevention and treatment of orthopedic-related diseases.