嗜黏蛋白阿克曼氏菌对代谢性疾病的治疗作用及机制的研究进展

Research progress on the therapeutic effect and mechanism of Akkermansia Muciniphila on metabolic diseases

代谢性疾病是一类由物质或能量代谢异常所引起的慢性疾病,包括肥胖、糖尿病及非酒精性脂肪肝病等,已严重危害人们的健康。研究表明,肠道菌群的失调与各种代谢性疾病的发生、发展密切相关,调控肠道菌群对改善代谢性疾病可能具有积极意义。嗜黏蛋白阿克曼氏菌是一种新型益生菌,可能通过修复肠道屏障,调控肠道菌群以及改善宿主代谢等机制对代谢性疾病产生保护作用。本文围绕肥胖、糖尿病及非酒精性脂肪肝病等疾病,综述嗜黏蛋白阿克曼氏菌对代谢性疾病的治疗作用及机制的研究进展,为临床治疗提供理论依据。

Metabolic diseases are a kind of chronic diseases caused by abnormal metabolism of matter or energy,including obesity,diabetes and non-alcoholic fatty liver disease,etc.,which have seriously harmed people’s health.Studies have shown that the imbalance of gut microbiota is closely related to the occurrence and development of various metabolic diseases,and the regulation of gut microbiota may have positive significance in improving metabolic diseases.Akkermansia muciniphila is a new type of probiotic,which may have protective effects on metabolic diseases by repairing intestinal barrier,regulating gut microbiota and improving host metabolism.In order to provide theoretical basis for clinical treatment,this paper reviews the research progress on the therapeutic effect and mechanism of Akkermansia muciniphila on metabolic diseases,including obesity,diabetes and nonalcoholic fatty liver disease.