多西环素联合克拉霉素治疗海分枝杆菌感染疗效观察

Efficacy of doxycycline combined with clarithromycin in the treatment of Mycobacterium marinum infection

目的:分析海分枝杆菌感染的临床特点及探讨多西环素联合克拉霉素治疗海分枝杆菌感染的疗效观察。方法:选取2020年3月至2023年2月于徐州医科大学附属连云港市第一人民医院皮肤科门诊确诊为海分枝杆菌感染的31例患者的临床资料,总结多西环素联合克拉霉素治疗效果。结果:所有患者确诊后口服克拉霉素联合多西环素治疗,平均治疗时间4.2个月。16例Ⅰ型患者平均治疗时间与15例Ⅱ型患者平均治疗时间相当,差异无统计学意义(t=0.205,P=0.839)。Ⅰ型患者中皮损直径<2 cm的平均治疗时间明显比皮损>2 cm的平均治疗时间短,差异有统计学意义(t=-2.771,P=0.015)。结论:多西环素联合克拉霉素治疗海分枝杆菌感染安全、有效,耐受性好。

Objective:To analyze the clinical characteristics of Mycobacterium marinum infection and explore the therapeutic effect of doxycycline combined with clarithromycin in the treatment of Mycobacterium marinum infection.Methods:The clini-cal data were collected from 31 patients diagnosed with Mycobacterium marinum infection in the Department of Dermatology,The Affiliated Lianyungang Hospital of Xuzhou Medical University,from March 2020 to February 2023.The therapeutic effect of doxycycline combined with clarithromycin was analyzed.Results:All patients were treated with clarithromycin combined with doxycycline after diagnosis.The average treatment time was 4.2months.The average treatment time of 16 patients with type I was similar to that of 15 patients with type II(t=0.205,P-0.839).The mean treatment time of patients with lesions<2 cm was significantly shorter than that of patients with lesions>2 cm(t=-2.771,P=0.015).Conclusion:Doxycycline combined with clarithromycin is safe,effective and well tolerated in the treatment of Mycobacterium marinum infection.