The mutual regulation between the pattern recognition receptor OsCERK1 and the E3 ubiquitin ligase OsCIE1 controls induction and homeostasis of immunity

模式相关受体OsCERK1与E3泛素化连接酶OsCIE1相互调节以维持免疫稳态

Plants have a multilayered immune system that includes pattern-triggered immunity(PTI)and effector-triggered immunity(ETI)to cope with pathogen attacks[1].PTI,also known as basal innate immunity,is initiated by the perception of microbe-/pathogen-associated molecular patterns(MAMPs/PAMPs)by pattern recognition receptors(PRRs).PRRs are cell surface-localized kinase complexes comprising receptor-like kinases(RLKs)and receptorlike proteins(RLPs).The majority of characterized RLKs structurally possess a variable extracellular domain(ECD),a single transmembrane(TM)region,and an intracellular kinase domain(KD),whereas RLPs lack an intracellular KD.The three most prevalent types of PRR ectodomains are leucine-rich repeats(LRR),multiple lysin motifs(LysM),and lectin domains.In the early stages of pathogen infection,PRR signaling is rapidly activated and triggers a series of immune responses,such as ROS bursts,callose deposition,and pathogenesis-related(PR)gene expression,to repel pathogenic microorganisms.