天然倍半萜内酯类成分抗胶质瘤作用机制的研究进展

Research progress on anti-glioma mechanism of natural sesquiterpene lactones

胶质瘤是一种常见的原发性颅内肿瘤,恶性胶质瘤死亡率高、预后极差,尽管采取多种治疗干预措施,总体生存率依旧很低。倍半萜内酯是一类含有α-亚甲基-γ-内酯的天然产物,具有较强的抗肿瘤活性,近几年来已有多项关于倍半萜内酯类化合物抗胶质瘤作用的报道,如ACT001,是一种倍半萜内酯(小白菊内酯)的结构修饰物,已作为一种潜在抗癌药物进入临床试验阶段。本文就近几年已有研究的具有抗胶质瘤作用的倍半萜内酯的活性及作用机制进行综述。

Glioma is a common primary intracranial tumor.Malignant glioma has a high mortality rate and an inferior prognosis.Despite various therapeutic interventions,the overall survival rate is still meager.Sesquiterpene lactone is a kind of natural product containingα-methylene-γ-lactone,which has strong anti-tumor activity.In recent years,there have been many reports on the anti-glioma effect of sesquiterpene lactone compounds,such as ACT001,which is a structural modification of sesquiterpene lactone(Parthenolide)and has entered the clinical trial stage as a potential anticancer drug.This paper reviews the activity and mechanism of sesquiterpene lactones with anti-glioma effects,which have been studied in recent.years.