白介素-6及其受体与多种健康结局:孟德尔随机化的证据图

Interleukin-6/Interleukin-6 receptor and multiple health outcomes:An evidence map of Mendelian randomization studies

目的通过证据图描述和总结白介素-6(IL-6)/白介素-6受体(IL-6R)与多种健康结局孟德尔随机化研究中的证据,明确其分布,以期为该领域研究提供参考。方法系统检索PubMed、EMBASE、Web of Science、Scopus、中国知识基础设施工程、中国生物医学文献服务系统、万方数据库、维普数据库中IL-6/IL-6R与多种疾病的孟德尔随机化研究,采用图表结合形式综合分析和展示纳入研究的基本信息、研究方法和研究结局。结果最终纳入38篇孟德尔随机化研究,2020年以后相关研究数增加趋势明显,纳入研究探讨IL-6、IL-6R、sIL-6R、gp130、IL-6RA 5种不同的表型和65种不同疾病间的因果关系。其中,遗传预测的IL-6水平与终末期肾病、精神分裂症、冠状动脉疾病和心房颤动存在因果关系,IL-6R与黑色素瘤、髓系白血病、膀胱癌、喉癌、眼癌和胆囊癌的发生率存在因果关系,sIL-6R水平与肺动脉高压、哮喘、抑郁、多发性硬化症、腹主动脉瘤等疾病患病率存在因果关系。结论孟德尔随机化研究提供了关于IL-6/IL-6R在多种健康结局中的因果作用的重要证据,涵盖精神心理、炎症、癌症和心血管疾病等,反映了IL-6/IL-6R在多种疾病中的广泛影响和IL-6领域研究的重要性。

Objective To describe and summarize current evidence on the causal relationship between interleukin-6(IL-6)/interleukin-6 receptor(IL-6R)and related health outcomes through a Mendelian randomization approach,so as to clarify the distribution of this evidence to provide a reference for research in this field.Method A systematic search was conducted in databases including PubMed,EMBASE,Web of Science,Sco pus,China National Knowledge Infrastructure,Chinese Biomedical Literature Service System,Wanfang,and VIP for Mendelian randomization studies on IL-6/IL-6R and related diseases.Basic information,research methods,and outcomes were comprehensively analyzed and presented using a combination of charts and tables.Results A total of 38 mendelian randomization studies were included.Since 2020,there has been a noticeable increase in the number of related studies,which explored the causal relationships between five different phenotypes(IL-6,IL-6R,sIL-6R,gp130,IL-6RA)and 65 different diseases.Among them,genetically predicted IL-6 levels were found to have a causal relationship with end-stage renal disease,schizophrenia,coronary artery disease and atrial fibrillation.IL-6R was causally related to the incidence rates of melanoma,myeloid leukemia,bladder cancer,laryngeal cancer,ocular cancer and gallbladder cancer.sIL-6R levels had a causal relationship with the prevalence of pulmonary arterial hypertension,asthma,depression,multiple sclerosis,and abdominal aortic aneurysm.Conclusion Mendelian randomization studies have provided important evidence on the causal role of IL-6/IL-6R in various health outcomes,covering mental health,inflammation,cancer and cardiovascular diseases,reflecting the broad impact of IL-6/IL-6R in multiple diseases and the significance of IL-6 research.